27284-91-9Relevant academic research and scientific papers
Far ultraviolet induced decomposition of thymine in deaerated and aerated aqueous solutions
Ohtani, Bunsho,Nagasaki, Hiroshi,Nishimoto, Sei-ichi,Sakano, Koichi,Kagiya, Tsutomu
, p. 2297 - 2300 (2007/10/02)
Thymine in aqueous solution was decomposed with quantum yields of 0.3 and 0.4 under N2-saturated and aerated conditions by far-ultraviolet light (>180 nm, far-uv), and quantum yields of 2E-4 and 3E-4 by near-ultraviolet light (>220 nm, near-uv), respectively.The main photolytic products by far-uv were 5,6-dihydrothymine (DHT) (selectivity: S(DHT) = 0.2) and 5-hydroxymethyluracil (HMU) (S(HMU) = 0.1) under N2-saturated conditions. cis- and trans-5,6-Dihydroxy-5,6-dihydrothymine (TG), 6(5)-hydroperoxy-5(6)-hydroxy-5,6-dihydrothymine (HTP) (S(TG) + S(HTP) = 0.2), and N1-formyl-N2-pyruvylurea (FPU) (S(FPU) = 0.4) were obtained under aerated conditions.These products were attributed to the reactions of thymine with the radical H and radical O produced by photolysis of water.
PROMOTION EFFECT OF 2,2,6,6-TETRAMETHYLPIPERIDINE-1-OXYLS ON THE RADIOLYTIC HYDROXYLATION OF THYMINE IN DEAERATED AQUEOUS SOLUTION
Kagiya, Tsutomu,Kimura, Ryoji,Komuro, Chikara,Sakano, Koichi,Nishimoto, Sei-ichi
, p. 1471 - 1474 (2007/10/02)
Remarkable promotion of the hydroxylation of thymine to give thymine glycol with almost complete depression of side reactions by 2,2,6,6-tetramethylpiperidine-1-oxyl (TMPO.) derivatives was observed in the γ-radiolyses of the N2- and N2O-saturated aqueous solutions.In the O2-saturated solution, TMPO. depressed the thymine conversion close to the level under N2 while promoted the formation of thymine glycol to some extent by decreasing side reactions.
