27294-08-2

Basic information

• Product Name: 5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester
• Synonyms: 5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester;ethyl 5-methoxy-3-phenyl-1H-indole-2-carboxylate
• CAS NO: 27294-08-2
• Molecular Formula: C₁₈H₁₇NO₃
• Molecular Weight: 295.34
• Mol File: 27294-08-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 113.5-114.5 °C
• Boiling Point: 507.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.202±0.06 g/cm3(Predicted)
• PKA: 14.46±0.30(Predicted)
• CAS DataBase Reference: 5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester(27294-08-2)
• EPA Substance Registry System: 5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester(27294-08-2)

Safety Data

• Hazardous Substances Data: 27294-08-2(Hazardous Substances Data)

Upstream product

• 620-79-1 Ethyl 2-benzylacetoacetate 

Downstream Products

• 127300-42-9 [1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indol-2-yl]-methanol 
• 138653-78-8 1-(2-Amino-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester 
• 138653-66-4 8-Methoxy-10-phenyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole 
• 136934-27-5 9-Methoxy-7-phenyl-5,6-dihydro-indolo[1,2-a]quinoxaline 
• 136934-22-0 9-Methoxy-7-phenyl-5H-indolo[1,2-a]quinoxalin-6-one 
• 105492-18-0 5-Methoxy-3-phenyl-1H-indole-2-carbonyl azide 
• 105492-22-6 (5-Methoxy-3-phenyl-1H-indol-2-yl)-carbamic acid ethyl ester 
• 105492-27-1 C₁₆H₁₆N₄O₂ 
• 106659-42-1 5-Methoxy-3-phenyl-1H-indole-2-carbaldehyde oxime 
• 59394-40-0 5-methoxy-3-phenyl-indole-2-carbaldehyde 
• 105492-14-6 5-methoxy-3-phenylindole-2-carboxyhydrazide 
• 59394-36-4 (5-methoxy-3-phenyl-indol-2-yl)-methanol 
• 127300-19-0 1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Novel method for synthesis of aryl hydrazones from α-diazo esters: scope and limitations of nucleophiles

Aryl hydrazones, the precursor of Fischer indole synthesis, were easily obtained by nucleophilic addition of aryllithium reagents to diazo esters. The aryl hydrazones were converted into indoles in good yields by heating with thionyl chloride in alcohol.

3-substituted indole antiproliferative angiogenesis inhibitors

3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.