273-98-3

Usage

Uses

Used in Pharmaceutical Industry:
THIAZOLO[4,5-B]PYRIDINE is used as a key building block for the development of new pharmaceuticals due to its potential in exhibiting various biological activities. Its derivatives have been studied for their anti-cancer, anti-inflammatory, anti-tuberculosis, and anti-microbial properties, making it a valuable component in the creation of innovative drugs to address a wide range of health issues.
Used in Agrochemical Industry:
In the agrochemical industry, THIAZOLO[4,5-B]PYRIDINE is utilized as a structural component in the design of new agrochemicals. Its unique properties allow for the development of compounds with potential applications in pest control, crop protection, and other agricultural areas, contributing to more effective and targeted solutions in this field.
Used in Materials Science:
THIAZOLO[4,5-B]PYRIDINE is employed as a component in the development of advanced materials due to its structural and functional characteristics. Its potential use in organic electronics and as a ligand in coordination chemistry highlights its versatility and applicability in creating materials with specific properties for various technological applications.
Used in Organic Electronics:
THIAZOLO[4,5-B]PYRIDINE is used as a component in organic electronics, where its unique structure and properties contribute to the development of innovative electronic devices and systems. Its potential use in this field highlights the compound's versatility and its role in advancing technology and electronic applications.
Used in Coordination Chemistry:
As a ligand in coordination chemistry, THIAZOLO[4,5-B]PYRIDINE is utilized for the synthesis of coordination compounds with specific properties and applications. Its unique structure allows for the creation of complexes with potential uses in various fields, including catalysis, sensing, and other specialized applications.

Upstream product

• 13534-99-1 2-Amino-3-bromopyridine 
• 13575-41-2 [1,3]thiazolo[4,5-b]pyridin-2-amine 
• 104830-06-0 3-iodo-2-aminopyridine 
• 67-68-5 dimethyl sulfoxide 

Relevant academic research and scientific papers

Synthetic method of ammonium acetate-mediated benzothiazole compound

The invention discloses a synthetic method of an ammonium acetate-mediated benzothiazole compound . The synthetic method comprises the steps: adding an o-haloaniline derivative, potassium sulfide, dimethyl sulfoxide, a catalyst, an additive 1 and an additive 2 into a reaction tube, carrying out a stirring reaction at the temperature of 130-150 DEG C, cooling to room temperature after the reactionis finished, and separating and purifying the product to obtain the benzothiazole compound. The invention provides the synthetic method of the benzothiazole compound by taking K2S as a sulfur source,DMSO as a carbon source and an oxidizing agent, an o-haloaniline derivative as a substrate and an ammonium acetate mediated three-component one-pot method. The method has the advantages of fewer reaction steps, mild reaction conditions, good functional group tolerance and the like.

K2S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles

We describe a three-component reaction of o-iodoanilines with K2S and DMSO that provides 2-unsubstituted benzothiazoles in moderate to good isolated yields with good functional group tolerance. Electron-rich aromatic amines and o-phenylenediamines instead of o-iodoanilines provided 2-unsubstituted benzothiazoles and 2-unsubstituted benzimidazoles with and without K2S under similar conditions. Notably, DMSO plays three vital roles: carbon source, solvent, and oxidant.

A thiazole pyridine compound and its preparation method

The invention relates to a thiazole pyridine compound and its preparation method. The compound is thiazolo(4,5-b)pyridine. The preparation method comprises the following steps: (1) a compound 13-bromine-2-aminopyridine is used as a starting material to react in the presence of benzoyl chloride and ammonium thiocyanate so as to obtain a benzoyl-protected thiourea-containing derivative compound 2; (2) the compound 2 undergoes hydrolysis to obtain a thiourea derivative compound; (3) the compound 3 undergoes ring closure under the action of NaH to generate a compound 4; and (4) the compound 4 undergoes deamination by the use of isoamyl nitrite to obtain a target product compound 5. According to the method, raw materials are cheap and easily available. The synthetic method is simple. The preparation method meets requirements of large-scale industrial production.