27314-77-8Relevant academic research and scientific papers
One-pot synthesis, molecular modeling and In Vitro antibacterial activity of novel 3-(1,3,4-Oxadiazol-2-yl) quinoxaline 1,4-dioxide and pyrazolyl analogs
Waly, Mohamed Attia,Abou-Zeid, Laila,Ramadan El-Gogary, Sameh,Shalaby, Mona Abbas
experimental part, p. 32 - 41 (2012/06/18)
The new 1,3,4-oxadiazolylquinoxaline ring system was synthesized by the condensation of the quinoxaline 1,4-dioxide acid hydrazide 6 with acetyl chloride in one-pot synthesis. In which the hydrazide was refluxed in excess of acetyl chloride, acetic anhydride or acetic acid in the presence of phosphorus oxychloride forming the 1,3,4-oxadiazolylquinoxaline ring system. Molecular modeling studies have been performed to evaluate their recognition at the hDHFR bindingpocket as potential hDHFR inhibitors. The antibacterial properties of these compounds showed reasonable activities towards gram negative bacteria, Escherichia coli. Compound 20 performed appropriate complementarity study rather well; the conserved amino acids of hDHFR enzyme imitating the MTX docking pattern. Besides, compound 20 showed highest antibacterial activity against E. coli in comparison with the well known bacteriostatic chloramphenicol; the pyrazolyl analogues also have moderate affinity toward the applied bacteria.
