27317-71-1

Upstream product

• 27317-68-6 Boc-Lys(Z)-Lys(Z)-OMe 
• 2389-45-9 Boc-Lys(Z)-OH 
• 27894-50-4 methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride 
• 34404-36-9 Boc-Lys(Z)-OSu 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 

Downstream Products

• 67866-17-5 α-BOC-di-ε-Z-lysyllysine N-hydroxysuccinimide ester 
• 69541-94-2 di-ε-Z-lysyllysine formate 
• 38126-37-3 Boc-L-Lys(Z)3-L-Ala-OMe 
• 75481-47-9 Boc-L-Lys(Z)3-L-Ala-OH 
• 55226-83-0 α-BOC-tetra-ε-Z-lys₄OH 
• 78746-22-2 α-BOC-ε-Z-lys₄OSu 
• 78746-21-1 HCOOH.NH2-ε-Z-lys₄OH 
• 1404363-71-8 C₃₉H₄₉N₅O₁₁ 
• 102633-60-3 C₆₂H₈₄N₈O₁₅ 
• 1404363-72-9 C₆₇H₈₅N₉O₁₇ 

Relevant academic research and scientific papers

CO2 in supramolecular chemistry: Preparation of switchable supramolecular polymers

CO2 gas was used to construct novel types of supramolecular polymers. Self-assembling nanostructures 11 and 13 were prepared, which employ both hydrogen bonding and dynamic, thermally reversible carbamate bonds. As precursors, calixarene ureas

Pillar[5]arene-Based Polycationic Glyco[2]rotaxanes Designed as Pseudomonas aeruginosa Antibiofilm Agents

Pseudomonas aeruginosa (P.A.) is a human pathogen belonging to the top priorities for the discovery of new therapeutic solutions. Its propensity to generate biofilms strongly complicates the treatments required to cure P.A. infections. Herein, we describe the synthesis of a series of novel rotaxanes composed of a central galactosylated pillar[5]arene, a tetrafucosylated dendron, and a tetraguanidinium subunit. Besides the high affinity of the final glycorotaxanes for the two P.A. lectins LecA and LecB, potent inhibition levels of biofilm growth were evidenced, showing that their three subunits work synergistically. An antibiofilm assay using a double δlecAδlecB mutant compared to the wild type demonstrated that the antibiofilm activity of the best glycorotaxane is lectin-mediated. Such antibiofilm potency had rarely been reached in the literature. Importantly, none of the final rotaxanes was bactericidal, showing that their antibiofilm activity does not depend on bacteria killing, which is a rare feature for antibiofilm agents.

Peptidic molecular brushes with enhanced chirality

Tethering oligopeptides through one end densely packed onto a linear polymer main chain will greatly reduce freedom of the peptide chains, which affords an easy access to investigate the secondary structure of peptides under constrained condition. Herein,

Supramolecular structures from lysine peptides and carbon dioxide

The design, synthesis, and characterization of novel linear and cross-linked supramolecular polymers that are easily available from biologically friendly lysine peptides and carbon dioxide (CO2) are reported here. Polymeric structures 5, 6, and

PROLINE DERIVATIVES

Proline derivatives of the formulae: STR1 wherein R 1 through R 11 have defined values, and acid-and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.