273216-27-6Relevant articles and documents
Nicotinyl aspartyl ketones as inhibitors of caspase-3
Isabel, Elise,Black, W. Cameron,Bayly, Christopher I.,Grimm, Erich L.,Janes, Marc K.,McKay, Daniel J.,Nicholson, Donald W.,Rasper, Dita M.,Renaud, Johanne,Roy, Sophie,Tam, John,Thornberry, Nancy A.,Vaillancourt, John P.,Xanthoudakis, Steven,Zamboni, Robert
, p. 2137 - 2140 (2003)
Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact in the treatment of several degenerative diseases. Since P1 aspartic acid is a required element of recognition for this enzyme, a