27332-20-3

Basic information

• Product Name: 2-AMINO-N-PHENYL-BENZENESULFONAMIDE
• Synonyms: BenzenesulfonaMide, 2-aMino-N-phenyl-
• CAS NO: 27332-20-3
• Molecular Formula: C₁₂H₁₂N₂O₂S
• Molecular Weight: 248.3009
• Mol File: 27332-20-3.mol

Chemical Properties

• Boiling Point: 439.8°Cat760mmHg
• Flash Point: 219.8°C
• Appearance: /
• Density: 1.373g/cm³
• Vapor Pressure: 6.19E-08mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 2-AMINO-N-PHENYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-PHENYL-BENZENESULFONAMIDE(27332-20-3)
• EPA Substance Registry System: 2-AMINO-N-PHENYL-BENZENESULFONAMIDE(27332-20-3)

Safety Data

• Hazardous Substances Data: 27332-20-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
2-Amino-N-phenyl-benzenesulfonamide is used as a chemical intermediate for various organic synthesis processes. Its unique structure allows it to be a valuable building block in the creation of more complex molecules, contributing to the advancement of organic chemistry.
Used in Industrial Applications:
2-Amino-N-phenyl-benzenesulfonamide is employed in different industries, where its chemical properties are utilized for specific purposes. The exact applications may vary, but its relevance in these sectors highlights the versatility of 2-AMINO-N-PHENYL-BENZENESULFONAMIDE in meeting various industrial needs.

InChI:InChI=1/C12H12N2O2S/c13-11-8-4-5-9-12(11)17(15,16)14-10-6-2-1-3-7-10/h1-9,14H,13H2

Upstream product

• 4837-33-6 o-nitrobenzenesulfenanilide 
• 23773-60-6 2-phenyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 587-14-4 N,N'-diphenylsulfamide 
• 62-53-3 aniline 
• 4837-32-5 S-(2-nitrophenyl)-N-(p-tolyl)thiohydroxylamine 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 101954-71-6 N-(2'-formamidobenzenesulfonyl)aniline 
• 5454-97-7 2-nitro-N-phenylbenzenesulfonamide 

Downstream Products

• 18127-45-2 2-phenyl-2H-benzo[e][1,2,3,4]thiatriazine-1,1-dioxide 
• 110194-85-9 3-oxo-3-phenyl-propionic acid-(2-phenylsulfamoyl-anilide) 
• 23773-60-6 2-phenyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 101954-71-6 N-(2'-formamidobenzenesulfonyl)aniline 
• 101954-59-0 3-methyl-2-phenyl-2H-1,2,4-benzothiadiazine 1,1,-dioxide 
• 91823-26-6 2-phenyl-3-thioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 1864-33-1 9,9-dioxo-10H-9-thia-10-aza-phenanthrene 
• 885683-53-4 C₁₈H₁₅N₃O₆S₂ 
• 885683-54-5 C₁₈H₁₇N₃O₄S₂ 
• 53347-49-2 2,2'-diaminodiphenyl sulfone 
• 88312-86-1 6-phenyl-6H-dibenzo<1,2>thiazin 5,5-dioxide 
• 120831-28-9 2-(4-diethylamino-2-methyl-phenylimino)-3-oxo-3-phenyl-propionic acid-(2-phenylsulfamoyl-anilide) 
• 203932-91-6 2-azido-N-phenylbenzenesulfonamide 

Relevant articles and documents

Palladium(0)-catalysed regioselective cyclisations of 2-amino(tosyl) benzamides/sulphonamides: The stereoselective synthesis of 3-ylidene-[1,4]benzodiazepin-5-ones/benzo[f][1,2,5]thiadiazepine-1,1-dioxides

The Pd(0) catalysed cyclisation reactions betweentert-butyl propargyl carbonates and 2-aminotosyl benzamides or sulphonamides deliver 1,4-benzodiazepin-5-ones or sultam derivatives, key components of many biologically active compounds. But 2-amino benzamides/sulphonamides require propargyl carbonates substituted at acetylenic carbon to undergo the reaction resulting in the stereoselective formation of the said products.

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Transition-Metal-Free Tandem Cyclization/ N-Arylation Reaction: A Method to Access Biaryl Sultam Derivatives via a Diradical Pathway

A novel procedure for the transition-metal-free tandem cyclization/N-arylation reaction sequence of an aryne with a 1,2,3,4-benzothiatriazine-1,1-dioxide is reported. This reaction goes through the intramolecular homolytic cyclization to generate an N-H b

Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies

A series of 24 benzothiadiazine derivatives with structural novelty were designed, synthesized and biologically evaluated as PI3Kδ-selective inhibitors. As a consequence of the structure-activity relationship (SAR) study, compounds 63 and 71 were identifi

Dibenzo[1,2,5]thiadiazepines are non-competitive GABAA receptor antagonists

A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABAA receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic compounds. An azide group was obtain

Photoinduced Ring Enlargement Reactions of 2H-1,2,4-Benzothiadiazine 1,1-Dioxides. Steady-State and Laser Flash Photolysis Studies

Ring-enlargement reactions of several 2H-1,2,4-benzothiadiazine 1,1-dioxides under photoexcitation have been studied by steady-state irradiation, product analysis, and laser flash photolysis.Irradiations in benzene or methanol gave moderate yields (14-70p