273378-16-8

Basic information

• Product Name: BOC-4-CYCLOHEXYL-PIPERIDINE-4-CARBOXYLIC ACID
• Synonyms: BOC-4-CYCLOHEXYL-PIPERIDINE-4-CARBOXYLIC ACID;4-Cyclohexyl-1,4-piperidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester;4-Cyclohexyl-1,4-piperidinedicarboxylic Acid tert-Butyl Ester;1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid
• CAS NO: 273378-16-8
• Molecular Formula: C₁₇H₂₉NO₄
• Molecular Weight: 311.42
• Product Categories: Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Isotope Labelled Compounds
• Mol File: 273378-16-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 436.5°C at 760 mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 7.68E-09mmHg at 25°C
• Refractive Index: 1.515
• PKA: 4.60±0.20(Predicted)
• CAS DataBase Reference: BOC-4-CYCLOHEXYL-PIPERIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-4-CYCLOHEXYL-PIPERIDINE-4-CARBOXYLIC ACID(273378-16-8)
• EPA Substance Registry System: BOC-4-CYCLOHEXYL-PIPERIDINE-4-CARBOXYLIC ACID(273378-16-8)

Safety Data

• Hazardous Substances Data: 273378-16-8(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

A piperidine derivative as melanocortin 4 receptor agonists and their pharmaceutical compositions for treatment of obesity, excessive appetite, sexual dysfunction, and infertility.

InChI:InChI=1/C17H29NO4/c1-16(2,3)22-15(21)18-11-9-17(10-12-18,14(19)20)13-7-5-4-6-8-13/h13H,4-12H2,1-3H3,(H,19,20)

Upstream product

• 167262-68-2 N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid 
• 674791-75-4 C₇H₈O₃S*C₁₂H₂₁NO₂ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-64-9 tert-butylamine 

Downstream Products

• 674792-27-9 fluoro-(D)-Phe,t-butyl amide dipeptide 
• 674791-76-5 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride 
• 747409-31-0 C₄₀H₅₈FN₅O₃ 
• 273378-19-1 N-Boc-4-cyclohexyl-4-piperidine-carboxylic acid dimethylamide 
• 1225652-85-6 4-cyclohexylpiperidine-4-carboxylic acid trifluoroacetate 
• 1225591-27-4 ethyl 1-tert-butoxycarbonyl-4-cyclohexylpiperidine-4-carboxylate 
• 852324-70-0 1-BOC-4-cyclohexyl-4-[(benzyloxycarbonyl)amino]piperidine 
• 852323-76-3 1-tert-butoxycarbonyl 4-tert-butylcarbamoyl-4-cyclohexylpiperidine 
• 363191-06-4 4-(2-tert-butoxycarbonylamino-propionyl)-2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 363190-30-1 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 363190-57-2 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-ethyl-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation

Dual NK2/NK3-antagonists corresponding to formula I: and physiologically compatible salts of such compounds in which X and R1 to R5 have specific defined meanings, pharmaceutical compositions containing such compounds, methods of using such compounds to treat or inhibit disorders mediated by tachykinin receptors, and a process for preparing such compounds.

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino] carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl] -4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. Further in vivo development of lead agonist, MB243, is disclosed.