27347-32-6

Basic information

• Product Name: 2,3-DIHYDRO-1-BENZOFURAN-2-CARBONYL CHLORIDE
• Synonyms: 2,3-DIHYDRO-1-BENZOFURAN-2-CARBONYL CHLORIDE;2,3-Dihydro-1-benzofurane-2-carbonylchloride;2-Benzofurancarbonyl chloride, 2,3-dihydro- (7CI,8CI,9CI);2,3-Dihydro-1-benzofuran-2-carbonyl chloride, tech;2,3-dihydrobenzofuran-2-carbonyl chloride
• CAS NO: 27347-32-6
• Molecular Formula: C₉H₇ClO₂
• Molecular Weight: 182.6
• Product Categories: ACIDHALIDE
• Mol File: 27347-32-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 270.5°Cat760mmHg
• Flash Point: 100.8°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 0.00683mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 2,3-DIHYDRO-1-BENZOFURAN-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1-BENZOFURAN-2-CARBONYL CHLORIDE(27347-32-6)
• EPA Substance Registry System: 2,3-DIHYDRO-1-BENZOFURAN-2-CARBONYL CHLORIDE(27347-32-6)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 27347-32-6(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-1-benzofuran-2-carbonyl chloride is a chemical compound with the molecular formula C9H7ClO2. It is a colorless liquid that is primarily used as an intermediate in organic synthesis to produce various pharmaceuticals, agrochemicals, and other fine chemicals. 2,3-DIHYDRO-1-BENZOFURAN-2-CARBONYL CHLORIDE is a versatile building block in the chemical industry due to its ability to undergo a wide range of chemical reactions, such as nucleophilic substitution, condensation, and addition reactions. Its reactivity and selectivity in organic reactions make it a valuable tool in the development of new chemical compounds with potential applications in medicine, agriculture, and material science.

InChI:InChI=1/C9H7ClO2/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-4,8H,5H2

Upstream product

• 108-95-2 phenol 
• 1746-13-0 allyl phenyl ether 
• 1745-81-9 o-Allylphenol 
• 66158-96-1 2-hydroxymethyl-1H-2,3-dihydrobenzofuran 
• 1914-60-9 2,3-dihydro-1-benzofuran-2-carboxylic acid 
• 496-41-3 Benzofuran-2-carboxylic acid 

Downstream Products

• 885041-05-4 5-(4-amino-phenyl)-6-(2,3-dihydro-benzofuran-2-yl)-pyrimidine-2,4-diamine 
• 885040-87-9 6-(2,3-dihydro-benzofuran-2-yl)-5-(4-nitro-phenyl)-pyrimidine-2,4-diamine 
• 1313727-86-4 N-{6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}-2,3-dihydro-1-benzofuran-2-carboxamide 
• 57537-75-4 2,3-Dihydrobenzo[b]furan-2-carboxamide 

Relevant articles and documents

Preparation of the I3 imidazoline receptor antagonist KU14R and related 2,3-dihydrobenzo[b]furan derivatives

The preparation and characterisation of a series of novel analogues of the imidazoline insulin secretagogue efaroxan, including the I3-receptor antagonist KU14R, are described. Replacement of the imidazoline ring of efaroxan by selected functional groups leads either to loss of activity or to very weak I3-agonist activity in insulin secretion studies. The imidazole analogue KU14R was found to be an I3-antagonist in this assay and useful as a biological tool.

Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation-Cyclization of Allylphenols

A green and cheap protocol for the synthesis of dihydrobenzofurans via an organocatalytic oxidation of o -allylphenols is presented. The use of 2,2,2-trifluoroacetophenone and H 2 O 2 as the oxidation system, leads to a highly useful synthetic method, where a variety of substituted o -allylphenols were cyclized in high yields..

α-Adrenoreceptor Reagents. 2. Effects of Modification of the 1,4-Benzodioxan Ring System on α-Adrenoreceptor Activity

Modification of the 1,4-benzodioxan ring present in RX 781094 (1) has not previously been considered.This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives.The dihydroxybenzofuranylimidazoline compound 7 is the only analogue possesing presynaptic antagonist potency and selectivity comparable to that of 1.In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series.Many derivatives, as well as the parent compound 7, were found to possess presynaptic α2-adrenoreceptor antagonist and postsynaptic α1-adrenoreceptor partial agonist properties.Two of the selective presynaptic antagonists,13 and 14, possess greater potency and selectivity than that possessed by 1.The 5-chloro derivative 25 is twice as potent as 1 after oral administration but only about half as potent when given intravenously.