2735-21-9

Usage

Uses

Used in Pharmaceutical Industry:
(3E,5alpha)-N-hydroxycholestan-3-imine is used as a pharmaceutical agent for its potential role in lipid metabolism. Its unique structure and properties make it a promising candidate for the development of new drugs targeting lipid-related disorders and conditions.
Used in Chemical Research:
(3E,5alpha)-N-hydroxycholestan-3-imine is used as a subject of study in chemical research to explore its properties, reactivity, and potential applications in various chemical processes. Its unique structure and the presence of a carbon-nitrogen double bond make it an interesting compound for further investigation and development.

Upstream product

• 566-88-1 dihydrocholesterone 
• 80-97-7 Cholestanol 

Downstream Products

• 15600-08-5 cholestan-3-one 
• 1912-64-7 3β-(acetylamino)-5α-cholestane 
• 1253-90-3 5α-cholestan-3β-yldimethylamine 
• 2206-20-4 3α-amino-5α-cholestane 
• 2206-21-5 3β-amino-5α-cholestane 

Relevant academic research and scientific papers

A hybrid molecule of a GFP chromophore analogue and cholestene as a viscosity-dependent and cholesterol-responsive fluorescent sensor

Diarylmethylenated and cholestene (or -tane)-hybrid analogues of the GFP chromophore, namely, Ch-DAINs were successfully synthesised by a condensation reaction between methyl imidates and N-(diarylmethylene)glycinates. Among the Ch-DAINs synthesised, a diphenyl-type analogue showed viscosity-dependent and cholesterol-responsive fluorescent properties. It showed a nearly linear increase of the fluorescence emission in triglycerides and vesicles as the amount of cholesterol was increased.

Convenient preparation of A-ring fused pyridines from steroidal enamides

A facile strategy for the preparation of A-ring fused pyridosteroids has been accomplished in high yields by the reaction of Vilsmeier reagent (chloromethyleneiminium salt) with steroidal A-ring enamides (2- and 3-ene) under thermal conditions. The structure of 6′-chloro-5α-cholest [3,2-b]pyridine was determined by X-ray analysis.

Resolution of conflicting migratory reports in ring expansion of 3-keto steroids to oxygen and nitrogen

The migration of C-2 and/or C-4 to O or N in the Beckmann, Schmidt, and Baeyer-Villiger reactions of 3-keto steroids has been studied with the aid of (13)Cmr spectroscopy.Authentic specimens of the eight possible lactone and lactam products from both 5α- and 5β-cholestan-3-one have been prepared; their physical properties and 13Cmr assignments are given.Seven ring expansion reactions reported to give only one product have been found to give both possible migration products.The much studied reactions of 5α-cholestan-3,6-dione and its derivatives have been reexamined.The results emphasize again the necessity of using 13C spectra both as an analytical tool and as the best criterion of purity in work with these molecules.