273720-77-7

Upstream product

• 271578-85-9 (R)-1-Benzyloxymethyl-5,7,8-trimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinolin-4-ol 
• 271578-77-9 2-(tert-butoxycarbonyl-methyl-amino)-3-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-phenyl]-propionic acid 

Downstream Products

• 273720-78-8 [2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-hydroxymethyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 273720-75-5 [2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(2-formyl-3,4,6-trimethoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 273720-74-4 {2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-1-[2,4,5-trimethoxy-6-(4-methoxy-benzyloxymethyl)-3-methyl-benzyl]-ethyl}-methyl-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

A novel face specific Mannich closure providing access to the saframycin-ecteinascidin series of piperazine based alkaloids

The Mannich-like closure of 10→6 directly provides the backbone stereochemistry required for the titled alkaloids, in contrast to the stereochemical outcome in a related earlier case (3→4). (C) 2000 Elsevier Science Ltd.

The solution to a deep stereochemical conundrum: Studies toward the tetrahydroisoquinoline alkaloids

(Chemical Equation Presented) Facile construction of subunits 1 and 2 allowed the rapid assembly of the pentacyclic ring system 3 of the cytotoxic tetrahydroisoquinoline alkaloids. A surprising participation reaction was discovered, which necessitated rev