273735-43-6

Basic information

• Product Name: 2,6-diMethyl-4-(perfluoropropan-2-yl)aniline
• Synonyms: 2,6-diMethyl-4-(perfluoropropan-2-yl)aniline
• CAS NO: 273735-43-6
• Molecular Formula: C₁₁H₁₀F₇N
• Molecular Weight: 289.1926224
• Mol File: 273735-43-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-diMethyl-4-(perfluoropropan-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-diMethyl-4-(perfluoropropan-2-yl)aniline(273735-43-6)
• EPA Substance Registry System: 2,6-diMethyl-4-(perfluoropropan-2-yl)aniline(273735-43-6)

Safety Data

• Hazardous Substances Data: 273735-43-6(Hazardous Substances Data)

Usage

General Description

2,6-diMethyl-4-(perfluoropropan-2-yl)aniline is a chemical compound that is commonly used as a precursor in the synthesis of various organic compounds. It is a derivative of aniline, with two methyl groups and a perfluoropropan-2-yl group attached to the 4-position of the benzene ring. This chemical is known for its high thermal stability and resistance to chemical reactions, making it useful in industrial applications. It is often used as a starting material in the production of dyes, pharmaceuticals, and agrochemicals. Additionally, it has potential uses in materials science, as it can be incorporated into polymers and other materials to improve their performance and durability.

Upstream product

• 87-62-7 2,6-dimethylaniline 
• 677-69-0 perfluoroisopropyl iodide 

Downstream Products

• 847622-55-3 N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 6-chloropyridine-2-carboxylic acid amide 
• 847622-53-1 N-(2,6-dimethyl-4-(perfluoropropan-2-yl)phenyl)-3-nitrobenzamide 
• 862132-84-1 N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-4-fluoro-3-nitro-benzamide 
• 847622-61-1 2-chloro-N-(2,6-dimethyl-4-(perfluoropropan-2-yl)phenyl)-3-nitrobenzamide 
• 936250-64-5 2-(tert-butoxycarbonyl)amino-N-(2,6-dimethyl-4-heptafluoroisopropylphenyl)-1,3-thiazole-4-carboxamide 
• 847622-66-6 N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl-3-(benzyloxycarbonyl)benzamide 
• 1187887-52-0 N-(2-chlorobenzoyl)-N'-(2,6-dimethyl-4-heptafluoroisopropylphenyl)urea 
• 1187887-38-2 N-(2,6-difluorobenzoyl)-N'-(2,6-dimethyl-4-heptafluoroisopropylphenyl)urea 
• 353272-62-5 2-iodo-1,3-dimethyl-5-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-benzene 
• 1000621-30-6 N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-2-fluoro-5-nitro-benzamide 
• 956830-52-7 5-nitrothiophene-3-carboxylic acid [2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethylethyl)phenyl]amide 
• 353273-15-1 2,6-dimethyl-4-heptafluoroisopropylphenylhydrazine Hydrochloride 
• 862134-85-8 N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 6-(benzoylamino)-1-oxopyridine-2-carboxylic acid amide 
• 862134-69-8 N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 6-(benzoylamino)pyridine-2-carboxylic acid amide 

Relevant articles and documents

Synthesis, insecticidal activities and SAR of novel phthalamides targeting calcium channel

In order to find novel and environmental friendly insecticides targeting the ryanodine receptor, three series of novel phthalamides containing heptafluoroisopropyl group, low fluorine atoms group and non-fluorine group were designed and synthesized. 35 novel structures of three series were obtained. Insecticidal activities of title compounds against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that most of title compounds showed moderate to high activities at the tested concentration. The structure-activity relationship (SAR) was discussed in detail. During synthesizing title compounds B8, C7, D1, D9 and D12, their corresponding positional isomers (B8′, C7′, D1′, D9′ and D12′) were afforded, and their structures were confirmed by 2D NMR. The calcium-imaging technique was also applied to investigate the effects of compounds B2, B10, C4 and C5 on the intracellular calcium ion concentration ([Ca2+]i), which indicated that they released stored calcium ions from endoplasmic reticulum, which denoted that some compounds are potential modulators of the insect ryanodine receptor (RyR).

Perfluoroalkylated aniline compound and process for producing the same

The present invention provides an aniline derivative represented by the formula (I) wherein R1 and R2 are each H, (C1-12)alkyl, (C3-8)cycloalkyl, hydroxy(C1-12)alkyl, hydroxycarbonyl (C1-12)alkyl, (C1-6)-alkoxycarbonyl(C1-6)alkyl, —COR8, wherein R8 is H, halo-(C1-12)alkyl, (C3-8)cycloalkyl or (substituted) phenyl, COOR9, wherein R9 is a halo(C1-6)alkyl group, (substituted) phenyl or (substituted) benzyl; R3, R4, R5, R6and R7 are each H, halogen, OH, nitro, halo(C1-12)alkylthio, (substituted)amino-(C1-2)alkyl, (substituted) phenyl, (substituted) benzyl, amino, —N(R10)R11 wherein R10 and R11 are each H, alkyl, cycloalkyl, (substituted) phenyl, (substituted) benzyl, —COR8 or COOR9, or (C2-27)perfluoroalkyl, etc., and a process for producing the aniline derivative. According to the process of the present invention, perfluoroalkylaniline derivatives can be obtained by using various anilines as the substrate with a high position selectivity and high yield.