273735-91-4

Upstream product

• 677-69-0 perfluoroisopropyl iodide 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1187887-57-5 N-(2,6-difluorobenzoyl)-N'-(2-heptafluoroisopropyl-4-methoxylphenyl)urea 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Site-Selective Trifluoromethylations and (Per)Fluoroalkylations of Anilines and Indoles

Introducing (per)fluoroalkyl groups into arenes continues to be an interesting, but challenging area in organofluorine chemistry. We herein report an ortho-selective C?H perfluoroalkylation including trifluoromethylations of anilines and indoles without the need of protecting groups using RfI and RfBr as commercially available reagents. The availability and price of the starting materials and the inherent selectivity make this novel methodology attractive for the synthesis of diverse (per)fluoroalkylated building blocks, for example, for bioactive compounds and materials.

Synthesis and insecticidal activity of heptafluoroisopropylcontaining benzoylphenylurea structures

Fourteen novel heptafluoroisopropyl-containing benzoylphenylureas were designed and synthesized. Their insecticidal activities against armyworm (Pseudaletia separata Walker) were examined and compared with the commercial product diflubenzuron. Three compounds (III, IIJ, and IIk) showed excellent insecticidal effect, and their activity resembled that of diflubenzuron. Compound III also showed nearly the same insecticidal activity as novaluron on African cotton leafworm (Spodoptera littoralis). Furthermore, results from a field trial indicated that 5% EC III exhibited similar efficacy in comparison with chlorfluazuron and hexaflumuron against imported cabbage worm (Pieris rapae L.) and diamondback moth (Plutella xylostella), respectively.

Perfluoroalkylated aniline compound and process for producing the same

The present invention provides an aniline derivative represented by the formula (I) wherein R1 and R2 are each H, (C1-12)alkyl, (C3-8)cycloalkyl, hydroxy(C1-12)alkyl, hydroxycarbonyl (C1-12)alkyl, (C1-6)-alkoxycarbonyl(C1-6)alkyl, —COR8, wherein R8 is H, halo-(C1-12)alkyl, (C3-8)cycloalkyl or (substituted) phenyl, COOR9, wherein R9 is a halo(C1-6)alkyl group, (substituted) phenyl or (substituted) benzyl; R3, R4, R5, R6and R7 are each H, halogen, OH, nitro, halo(C1-12)alkylthio, (substituted)amino-(C1-2)alkyl, (substituted) phenyl, (substituted) benzyl, amino, —N(R10)R11 wherein R10 and R11 are each H, alkyl, cycloalkyl, (substituted) phenyl, (substituted) benzyl, —COR8 or COOR9, or (C2-27)perfluoroalkyl, etc., and a process for producing the aniline derivative. According to the process of the present invention, perfluoroalkylaniline derivatives can be obtained by using various anilines as the substrate with a high position selectivity and high yield.