273749-54-5Relevant articles and documents
Synthesis of two hyaluronan trisaccharides
Yeung, Bryan K. S.,Hill, Daniel C.,Janicka, Maria,Petillo, Peter A.
, p. 1279 - 1282 (2007/10/03)
(equation presented) The synthesis of two hyaluronan trisaccharides, methyl O-(β-D-glucopyranosyluronic acid)-(1,3)-O(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1,4)-O-β-D- glucopyranosiduronic acid and methyl O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1,4)-O-β-D- glycopyranosyluronic acid)-(1,3)-O-(2-acetamido-2-deoxy-β-D-glucopyranoside, are described. Construction of the target molecules was achieved though a combination of the phenyl sulfoxide and trichloroacetimidate glycosylation methodologies. This is the first report on the synthesis of the β-methyl derivatives, which represent the smallest fragments that incorporate all the structural features of polymeric hyaluronan.