2739-17-5

Upstream product

• 91-22-5 quinoline 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 

Downstream Products

• 18502-95-9 4-chloro-N-(3,4-dihydro-2H-quinolin-1-yl)-3-sulfamoyl-benzamide 
• 5825-45-6 1-amino-1,2,3,4-tetrahydroquinoline 
• 5825-44-5 N-nitroso-1,2,3,4-tetrahydroquinoline 
• 262853-30-5 3,4-dihydro-2H-quinoline-1-carbothioamide 
• 73855-31-9 1,3-bis-(3,4-dihydro-2H-[1]quinolyl)-trimethinium ; chloride 

Relevant academic research and scientific papers

Method for preparing amine compound by reducing amide compound

The invention relates to a method for preparing an amine compound by reducing an amide compound, which comprises the following steps: in a protective atmosphere, mixing the amide compound or cyclic amide, a zirconium metal catalyst and pinacol borane, carrying out amide reduction reaction at room temperature, and carrying out aftertreatment by using an ether solution of hydrogen chloride after 12-48 hours to obtain an amine hydrochloride compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate range.

Reduction of isoquinoline and pyridine-containing heterocycles with lithium triethylborohydride (Super-Hydride)

Isoquinolines, quinoline and pyridines are effectively reduced to 1,2,3,4-tetrahydroisoquinolines, 1,2,3,4-tetrahydroquinolines and piperidines respectively with lithium triethylborohydride (Super-Hydride). The mechanism of the reduction was explored by reduction of isoquinoline and pyridine with lithium triethylborodeuteride (Super-Deuteride).