273926-75-3

Upstream product

• 591-51-5 phenyllithium 
• 273926-74-2 1:2,9:10 cyclic carbonate-2,9,10,13-pentadeacetyl-7-deacetoxy-13-oxo baccatine IV 
• 273926-64-0 5-O-triethylsilyl-2,9,10-triacetyltaxicin-I 
• 273926-72-0 C₂₉H₄₄O₁₂SSi 
• 273926-70-8 C₂₈H₄₂O₁₀Si 
• 273926-68-4 C₂₈H₄₀O₈Si 
• 273926-66-2 (1S,2S,3R,5S,8R,9R,10R)-1,2,9,10-Tetrahydroxy-8,12,15,15-tetramethyl-4-methylene-5-triethylsilanyloxy-tricyclo[9.3.1.0^3,8]pentadec-11-en-13-one 
• 273926-52-6 C₂₂H₂₈O₁₀ 
• 273926-73-1 1:2,9:10 cyclic carbonate-2,4,9,10,13-pentadeacetyl-7-deacetoxy-13-oxo baccatine IV 
• 273926-56-0 C₂₂H₂₆O₈ 
• 158137-46-3 2α,9α,10β-triacetyl taxicin-I 
• 13452-36-3 2,9,10-triacetyl-5-O-cinnamoyltaxicin-I 

Downstream Products

• 273926-83-3 C₃₆H₄₀O₁₀ 
• 273926-84-4 C₅₂H₅₃NO₁₃ 
• 273926-79-7 C₅₂H₆₄N₅O₁₅PSi 
• 273926-80-0 C₅₂H₆₆N₅O₁₅PSi 
• 273926-82-2 C₃₆H₃₈O₁₀ 
• 273926-78-6 C₄₆H₅₀N₅O₁₅P 

Relevant academic research and scientific papers

The synthesis and biological activity of 9- and 2'-cAMP 7- deoxypaclitaxel analogues from 5-cinnamoyltriacetyltaxicin-I

The synthesis and biological activity of new 7-deoxypaclitaxel analogues 3 and 4 in which the hydroxy group at C-2' of the side-chain, C-9 and C-10 in the B-ring are substituted by cAMP and benozoyloxy group respectively are presented. These derivatives have been first synthesized from a natural taxoid 5-cinnamoyltriacetyltaxicin-15 and tested in vitro for cytotoxicity against three human tumor cell lines. The biologically tested results indicate 3 having more potent cytotoxicity and 4 having a remarkably reduced cytotoxicity as well as 33 having no much effect on cytotoxicity against all human tumor cell lines tested in comparison to that of paclitaxel. (C) 2000 Elsevier Science Ltd.