273937-71-6

Basic information

• Product Name: 2-Phenyl-6-(trifluoromethyl)pyridine
• Synonyms: 2-Phenyl-6-(trifluoromethyl)pyridine
• CAS NO: 273937-71-6
• Molecular Formula: C12H8F3N
• Molecular Weight: 223.19
• Mol File: 273937-71-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenyl-6-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-6-(trifluoromethyl)pyridine(273937-71-6)
• EPA Substance Registry System: 2-Phenyl-6-(trifluoromethyl)pyridine(273937-71-6)

Safety Data

• Hazardous Substances Data: 273937-71-6(Hazardous Substances Data)

Upstream product

• 887144-94-7 Togni's reagent II 
• 1131-33-5 2-phenylpyridin N-oxide 
• 1008-89-5 2-phenylpyridine 
• 52806-02-7 iodure de 1-methyl-2-phenylpyridinium 
• 76-05-1 trifluoroacetic acid 
• 603-33-8 triphenylbismuthane 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 536-74-3 phenylacetylene 
• 98-80-6 phenylboronic acid 
• 100-58-3 phenylmagnesium bromide 

Relevant articles and documents

Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer

We report a general protocol for the direct C-H etherification of N-heteroarenes. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.

Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents

A mild cross-coupling reaction of heteroaryl sulfinates with Grignard reagents has been developed under transition-metal-free conditions. This study provides an example of the SO22- as a leaving group in an aromatic system and an effective methodology for the construction of C-C bond.

Towards environmentally friendlier Suzuki-Miyaura reactions with precursors of Pd-NHC (NHC = N-heterocyclic carbene) complexes

The preparation of [NHC·H][Pd(η3-R-allyl)Cl2] complexes is disclosed and represents a facile, atom-economical, environmentally friendly and rapid synthesis. These palladates are immediate synthetic precursors to the well-known [Pd(NHC)(η3-R-allyl)Cl] complexes. Their activation leading to catalytically relevant species has been studied in the Suzuki-Miyaura reaction. The need for an activation step prior to the catalysis was examined. The reaction scope showcases its ease and breadth in terms of functional group tolerance. Electron-donating and electron-withdrawing aryl chlorides and bromides were coupled effectively as well as heteroatom-containing and sterically hindered aryl halides. The catalytic reaction was conducted in ethanol with a weak and inexpensive inorganic base.