27398-52-3Relevant academic research and scientific papers
SAR Studies of N-[2-(1 H-Tetrazol-5-yl)phenyl]benzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists
Wei, Lai,Hou, Tao,Lu, Chang,Wang, Jixia,Zhang, Xiuli,Fang, Ye,Zhao, Yaopeng,Feng, Jiatao,Li, Jiaqi,Qu, Lala,Piao, Hai-Long,Liang, Xinmiao
supporting information, p. 422 - 427 (2018/05/23)
G protein-coupled receptor-35 (GPR35) has emerged as a potential target in the treatment of pain and inflammatory and metabolic diseases. We have discovered a series of potent GPR35 agonists based on a coumarin scaffold and found that the introduction of
DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS
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Page 36, (2008/06/13)
The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.
