274-82-8

Usage

Chemical Properties

Brown solid

InChI:InChI=1/C5H4N4/c1-2-9-4-7-8-5(9)3-6-1/h1-4H

Upstream product

• 74803-29-5 1,2,4-Triazolo<3,4-c>pyrazine 7-Oxide 
• 54608-52-5 2-hydrazinylpyrazine 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 345311-09-3 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 
• 723286-81-5 7-(tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine 
• 723286-80-4 3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 
• 723286-79-1 tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 
• 1438072-05-9 N-(3-chloro-4-fluorophenyl)-6-(3-(5.6-dihydro-[1,2,4]triazolo[4.3-a]pyrazin-7(8H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-81-7 N-(4-bromo-2-fluorophenyl)-6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-63-5 6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-N-(3-ethynylphenyl)-7-methoxyquinazolin-4-amine 
• 1438074-45-3 6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-N-(3-ethynyl-4-fluorophenyl)-7-methoxyquinazolin-4-amine 
• 1438074-28-2 6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-N-(4-fluorophenyl)-7-methoxyquinazolin-4-amine 
• 68774-81-2 1,2,4-triazolo<4,3-a>pyrazin-8(7H)-one 
• 74803-30-8 8-anilino-1,2,4-triazolo<4,3-a>pyrazine 

Relevant academic research and scientific papers

3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Ring Opening or Rearrangement versus N-Oxidation in the Action of Peracids upon Pyrrolopyridines, Pyrrolopyrazines, and Triazolo- and Triazolo-pyrazine. Some Chemical and Spectroscopic Properties of the Triazolopyrazines and Th

Peracid oxidation of the title heterocycles has shown a variety of reaction pathways. 1-Methyl-2,3-diphenyl-1H-pyrrolopyridine (8) gave a ring-opening product (13), while 3-methyl-2-phenyl-1H-pyrrolopyrazine gave N-benzoylurea.In contrast, t