2740-25-2

Basic information

• Product Name: 2-propanoyl-1H-indene-1,3(2H)-dione
• Synonyms: 1H-indene-1,3(2H)-dione, 2-(1-oxopropyl)-; 2-Propionyl-1H-indene-1,3(2H)-dione; 2-propionylindane-1,3-dione
• CAS NO: 2740-25-2
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.206
• Mol File: 2740-25-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 380.1°C at 760 mmHg
• Flash Point: 165.8°C
• Density: 1.269g/cm³
• Vapor Pressure: 5.6E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 2-propanoyl-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propanoyl-1H-indene-1,3(2H)-dione(2740-25-2)
• EPA Substance Registry System: 2-propanoyl-1H-indene-1,3(2H)-dione(2740-25-2)

Safety Data

• Hazardous Substances Data: 2740-25-2(Hazardous Substances Data)

Upstream product

• 84-66-2 Diethyl phthalate 
• 78-93-3 butanone 
• 131-11-3 phthalic acid dimethyl ester 

Downstream Products

• 1609240-24-5 2-(1-(2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazono)propyl)-1H-indene-1,3(2H)-dione 
• 1609240-23-4 2-(1-(2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)propyl)-1H-indene-1,3(2H)-dione 
• 1609240-22-3 2-(1-(2-(4-p-tolylthiazol-2-yl)hydrazono)propyl)-1H-indene-1,3(2H)-dione 
• 1609240-21-2 2-(1-(2-(4-phenylthiazol-2-yl)hydrazono)propyl)-1H-indene-1,3(2H)-dione 
• 1609240-40-5 4-(4-chlorophenyl)-2-(3-ethylindeno[1,2-c]pyrazol-1(4H)-yl)thiazole 
• 1609240-39-2 2-(3-ethylindeno[1,2-c]pyrazol-1(4H)-yl)-4-(4-methoxyphenyl)thiazole 
• 1609240-38-1 2-(3-ethylindeno[1,2-c]pyrazol-1(4H)-yl)-4-p-tolylthiazole 
• 1609240-37-0 2-(3-ethylindeno[1,2-c]pyrazol-1(4H)-yl)-4-phenylthiazole 
• 1609240-32-5 1-(4-(4-chlorophenyl)thiazol-2-yl)-3-ethylindeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-31-4 3-ethyl-1-(4-(4-methoxyphenyl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-30-3 3-ethyl-1-(4-p-tolylthiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-29-0 3-ethyl-1-(4-phenylthiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-one 

Relevant articles and documents

Synthesis, antimicrobial evaluation, α-amylase inhibitory ability and molecular docking studies of 3-alkyl-1-(4-(aryl/heteroaryl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-ones

A series of thiazole tethered indenopyrazoles has been synthesized and assayed for their antimicrobial and α-amylase inhibitory activities. Ciprofloxacin and Fluconazole were used as standard drugs for antibacterial and antifungal evaluation, respectively while Acarbose was used as standard reference for α-amylase inhibitory activity. The antimicrobial activity evaluation results revealed that derivative 3d showed highest potency against two Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus), two Gram-negative bacterial strains (Escherichia coli and Pseudomonas aeruginosa) with MIC values of 0.0541 μmol/mL, 0.0270 μmol/mL, 0.0270 μmol/mL, 0.0270 μmol/mL, respectively and two fungal strains (Candida albians and Aspergillus niger) with MIC values of 0.0067 μmol/mL and 0.0270 μmol/mL, respectively in comparison to the standard drugs Ciprofloxacin (MIC = 0.0094 μmol/mL) and Fluconazole (MIC = 0.0408 μmol/mL). Interestingly, all the compounds of the series except 3e exhibited better inhibitory activity against C. albicans with MIC value ranging from 0.0067 to 0.0297 μmol/mL than the standard drug Fluconazole. However, derivatives 3j with IC50 value of 0.79 μM and 3k with IC50 value of 0.46 μM were recognized as good α-amylase inhibitors as compared to the reference drug Acarbose (IC50 = 0.11 μM). Further, the docking studies were performed to support the results of biological activities.