27404-62-2Relevant academic research and scientific papers
Diastereo- And Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade
Lu, Shenci,Ong, Jun-Yang,Yang, Hui,Poh, Si Bei,Liew, Xi,Seow, Chwee San Deborah,Wong, Ming Wah,Zhao, Yu
supporting information, p. 17062 - 17067 (2019/11/03)
We present herein an unprecedented stereoselective synthesis of bridged biaryls with defined axial and central chirality from readily available starting materials. This N-heterocyclic carbene-catalyzed method proceeds through propargylic substitution of azolium enolates followed by two-directional cyclization, as supported by DFT calculation. A range of benzofuran/indole-derived bridged biaryls bearing an eight-membered lactone are accessed with uniformly high stereoselectivity (>98:2 dr, mostly >98% ee).
Preparation method of 2,2'-dihydroxy diphenyl ketone compound
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Paragraph 0086; 0087, (2018/09/11)
The invention relates to a preparation method of a 2,2'-dihydroxy diphenyl ketone compound. The method belongs to the technical field of ketone acyclic compound synthesis, and comprises the steps of adopting 5-alkyl-3-[5-alkyl-2-hydroxycyclohexyl phenyl ketone]benzofuran-2-(3 hydrogen)-ketone as a raw material, dissolving in a solvent, adding an anhydrous alkali catalyst, feeding oxygen or air, and carrying out oxidation reaction. The preparation method provided by the invention is applied to preparing the dihydroxy diphenyl ketone compound and has the advantages of concise steps, green synthesis without pollution, high yield and the like.
Preparation method of 2,2'-dyhydroxy benzophenone compound
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, (2018/09/11)
The invention relates to a preparation method of a 2,2'-dyhydroxy benzophenone compound, and belongs to the technical field of synthesis of ketone acyclic compounds. 2,2-di(2-hydroxy-5-alkylphenyl)methyl acetate is taken as a raw material, an anhydrous base catalyst is added after the raw material is dissolved in a solvent, oxygen or air is injected to conduct an oxidation reaction, and the compound is prepared. The preparation method is applied to preparation of the dyhydroxy benzophenone compound, and has the advantages that the steps are easy and simple, the synthesis process is green and free of pollution, and the yield is high.
Rh-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones
Rao, Maddali L. N.,Ramakrishna, Boddu S.
, p. 75505 - 75511 (2016/08/24)
An efficient rhodium-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones was developed from functionalized salicylaldehydes. This approach provides an easy access to various functionalized 2,2′-dihydroxybenzophenone and xanthone core s
