274250-97-4

Upstream product

• 6281-32-9 4-quinolylmethanol 
• 586-75-4 4-chlorobenzoyl chloride 
• 4363-93-3 quinoline-4-carboxaldehyde 

Downstream Products

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 93-58-3 benzoic acid methyl ester 

Relevant academic research and scientific papers

4-Quinolylmethyl and 1-naphthylmethyl as benzyl-type protecting groups of carboxylic acids removable by homogeneous palladium-catalyzed hydrogenolysis

4-Quinolylmethyl (4-QUI) esters are reduced by palladium-catalyzed hydrogenolysis by formate anion. The reaction conditions are compatible with reducible substituents or functional groups as aromatic bromo, alkene, aldehyde, ketone, nitrile, ethyl and benzyl esters. An allyl ester is cleaved selectively in the presence of a 4-QUI ester. 1-Naphthylmethyl (1-NAP) esters of α-amino acids could be deprotected without any racemization by the same methodology. (C) 2000 Elsevier Science Ltd.