27429-31-8Relevant academic research and scientific papers
Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules
Saikia, Ananya Anubhav,Rao, Ramdas Nishanth,Maiti, Barnali,Balamurali, Musuvathi Motilal,Chanda, Kaushik
, p. 630 - 640 (2020/12/15)
In this work, a one-pot, telescopic approach is described for the combinatorial library of thiazolidine-2-imines. The synthetic manipulation proceeds smoothly via the reaction of 2-aminopyridine/pyrazine/pyrimidine with substituted isothiocyanates followed by base catalyzed ring closure with 1,2-dibromoethane to obtain thiazolidine-2-imines with broad substrate scope and high functional group tolerance. The synthetic strategy merges well with the thiourea formation followed by base catalyzed ring closure reaction for the thiazolidine-2-imine synthesis in a more modular and straightforward approach. The synthetic procedure reported herein represents a cleaner route toward thiazolidine-2-imines as compared to traditional methodologies. Moreover, the biological significance of combinatorially synthesized thiazolidin-2-imines has been investigated for their use as possible inhibitors for acetyl cholinesterase through molecular docking studies.
Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones
Kumar,Singh,Pandeya
, p. 238 - 242 (2007/10/03)
[N-(2-pyridyl)-N'-(4-(un) substituted] thioureas and (substitutedaryl)thiosemicarbazones were synthesised and evaluated for their antibacterial activity. All aryl thiosemicarbazones showed good activity against Aeromonas hydrophilia and Salmonella typhimuriurn. But none of the pyridyl thioureas showed any prominent activity against tested bacteria.
Structural and spectral studies of N-(2-pyridyl)-N'-tolylthioureas
Valdes-Martinez, Jesus,Hernandez-Ortega, Simon,West, Douglas X.,Ackerman, Lily J.,Swearingen, John K.,Hermetet, Anne K.
, p. 219 - 226 (2007/10/03)
N-(2-pyridyl)-N'-o-tolylthiourea, monoclinic, P21/c, a = 5,127(1), b = 19.854(2), c = 12.077(2), A, β = 94.96(1)°, V = 1224,7(2) A3, Z = 4, μ = 2.177 mm-1, N-(2-pyridyl)-N'-m-tolylthiourea, triclinic, P - 1, a = 9.811(2),
Interactions between substituted thioureas and π-acceptors
Mohamed,Hassan,Ibrahim,Semida,Mourad
, p. 592 - 595 (2007/10/02)
Charge-transfer (CT) interactions between some N-aryl-N'-heterocyclic thioureas and both tetracyanoethylene (TCNE) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) were investigated spectroscopically. The formed CT complexes and the solvent effect on CT complexation are discussed. N-Aryl-N'-(2-pyridyl)-thioureas 1 a-d reacted with TCNE to give cyanothiourea derivatives 6, however in case of DDQ, the adducts 7 were obtained.
Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates
Dhasmana,Barthwal,Pandey,et al.
, p. 635 - 637 (2007/10/02)
Eight 1-aryl-3-(2-pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20-60% protection against pentylenetetrazol-induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD50 values which were found to range from 500-1000 mg/kg. All substituted thiobarbiturates (1mM) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10-72%.
