27430-12-2Relevant academic research and scientific papers
Features of the synthesis of thiobarbituric acid arylidene derivatives in the presence of triethylamine
Rahimov,Avdeev
, p. 2412 - 2416 (2009)
The synthesis of thiobarbituric acid arylidene derivatives proceeds in two steps, which include 5-(2-hydroxy-2-phenyl)ethyl derivative formation and dehydration. The triethylamine promotes increase in the negative charge on the 5th carbon atom (from -0.39
Spectrophotometric determination and kinetic studies of condensation of aromatic aldehydes with 2-thiobarbituric acid
Medien,Zahran
, p. 1069 - 1080 (2003)
The condensation reaction of 2-thiobarbituric acid with aromatic aldehydes in ethanol has been investigated spectrophotometrically at 30-50°C. The reaction was catalyzed by HCl solutions. The reaction follows overall second order kinetics, first order eac
Thiobarbiturates as potential antifungal agents to control human infections caused by Candida and Cryptococcus species
Shabeer, Muhammad,Barbosa, Luiz C. A.,Karak, Milandip,Coelho, Amanda C. S.,Takahashi, Jacqueline A.
, p. 1043 - 1049 (2018/03/26)
Hospitalized patients can suffer from Candida and Crytptococcus infections, aggravating underlying health conditions. Due to the development of drug-resistant microorganisms, we report here on the potential of some arylidene-thiobarbiturate to control fiv
Sulfamic Acid Catalyzed Atom Economic, Eco-friendly Synthesis of Novel 7-(Aryl)-10-thioxo-7,9,10,11-tetrahedro-6H-pyrimido-[5′4′:5,6]pyrano[3,2-c]quinoline-6,8(5H)-dione and its Derivatives
Jadhav, Sunetra J.,Patil, Reshma B.,Kumbhar, Digambar R.,Patravale, Ajinkya A.,Chandam, Dattatraya R.,Deshmukh, Madhukar B.
, p. 2206 - 2215 (2017/07/25)
A series of novel 7-(3-chloro-phenyl)-10-thioxo-7,9,10,11-tetrahedro-6H-pyrimido-[5′4′:5,6] pyrano[3,2-c]quinoline-6,8(5H)-dione derivatives have been synthesized through the multi-component condensation of aromatic aldehydes, barbituric acid, and 2,4-dih
Composition for trichogenousness
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Paragraph 0093-0095; 0156-0157; 0164-0165, (2017/08/08)
The present invention relates to novel barbiturate and thiobarbiturate derivatives and a composition for promoting hair growth using the same. According to the present invention, the barbiturate and thiobarbiturate derivatives, in an animal model, have shown to promote hair growth and have excellent effects on hair growth by promoting regulation of Wnt/andbeta;-catenin and hair growth factor signaling and suppressing mechanism of apoptosis. Accordingly, the barbiturate and thiobarbiturate derivatives of the present invention may be used as a composition for promoting hair growth.COPYRIGHT KIPO 2017
Urotropine-bromine promoted synthesis of functionalized oxaspirotricyclic furopyrimidines via a domino Knoevenagel condensation/Michael addition/α-bromination/Williamson cycloetherification sequence in water
Teimouri, Mohammad Bagher,Akbari-Moghaddam, Peyman,Motaghinezhad, Mahnaz
, p. 6804 - 6809 (2013/07/26)
An efficient, safe and facile route to functionalized spiro[furo[2,3-d] pyrimidine-6,5′-pyrimidine] derivatives has been developed by a one-pot pseudo three-component domino coupling of aromatic aldehydes and (thio)barbituric acids in the presence of urot
Spectral, coordination and thermal properties of 5-arylidene thiobarbituric acids
Masoud, Mamdouh S.,El-Marghany, Adel,Orabi, Adel,Ali, Alaa E.,Sayed, Reham
, p. 179 - 187 (2013/04/24)
Synthesis of 5-arylidine thiobarbituric acids containing different functional groups with variable electronic characters were described and their Co2+, Ni2+ and Cu2+ complexes. The stereochemistry and mode of bonding of 5-
New strategy for the synthesis of 5-Aryl-1H,1′H-spiro[furo[2,3-d] pyrimidine-6,5′-pyrimidine]2,2′,4,4′,6′(3H,3'H,5H) -pentaones and their sulfur analogues
Jalilzadeh, Mohammad,Pesyan, Nader Noroozi
experimental part, p. 3382 - 3388 (2012/01/19)
Reaction of barbituric acid (BA), 1,3-dimethyl barbituric acid (DMBA) and 2-thiobarbituric acid (TBA) with cyanogen bromide and aldehydes in the presence of L-(+)-tartaric acid afforded a new route for the synthesis of stable heterocyclic 5-aryl-1H,1′H-spiro[furo[2,3-d]pyrimidine-6,5′- pyrimidine]2,2′,4,4′,6′(3H,3′H,5H)- pentaones which is a dimeric form of barbiturate (uracil and thiouracil derivative). In the reaction of 1,3-diethyl thiobarbituric acid (DETBA) the Knoevenagel condensation and then Michael adducts were obtained under the same condition. Structure elucidation is carried out by 1H NMR, 13C NMR, FT-IR and Mass analyses. Mechanism of the formation is discussed.
Facile syntheses of bioactive 5-arylidenethiobarbituric acids
Sharif, Ahsan,Ahmed, Ejaz,Munawar, Munawar Ali,Jabeen, Shamsa,Khan, Misbah-Ul-Ain,Begum, Robina,Farrukh, Aleeza,Ashraf, Muhammad,Arshad, Shafia,Afza, Nighat
experimental part, p. 578 - 586 (2012/01/05)
A simple and green chemistry route for the preparation of 5-arylidenethiobarbituric acids has been developed by Knoevenagel condensation of thiobarbituric acid with different aromatic and heteroaromatic aldehydes using catalytic amount of acetic acid by g
Molecular diversity of the three-component reactions of N-benzylbenzimidazolium salts, aromatic aldehydes, and active methylene compounds
Hui, Li,Jin, Yu-Xiu,Wang, Jin-Xiu,Yan, Chao-Guo
supporting information; experimental part, p. 7194 - 7198 (2012/01/30)
The three-component reactions of in-situ-formed N-benzylbenzimidazolium salts, aromatic aldehydes, and active methylene compounds in the presence of triethylamine showed very interesting molecular diversity. The reactions with Meldrum's acid or barbiturate in acetonitrile gave a series of the novel zwitterionic salts in high yields. Under similar reaction conditions, the reactions with malononitrile or ethyl cyanoacetate produced functionalized pyrrolo[1,2-a]benzimidazoles in good yields with an unprecedented regioselectivity.
