27446-08-8

Upstream product

• 5424-06-6 3-amino-1,2,4-benzotriazine 1-oxide 

Downstream Products

• 67692-91-5 3-chloro-1,2,4-benzotriazine 1-oxide 
• 83702-25-4 4-Benzyl-4H-benzo-1,2,4-triazin-3-one 1-Oxide 
• 83702-32-3 4-(2-Hydroxyethoxymethyl)-4H-benzo-1,2,4-triazin-3-one 1-Oxide 
• 83702-30-1 4-(2-Acetoxyethoxymethyl)-4H-benzo-1,2,4-triazin-3-one 1-Oxide 
• 91669-21-5 3-chlorobenzo[e][1,2,4]triazine 
• 77475-32-2 ethyl 2-(benzo[e][1,2,4]triazin-3-yl)acetate 
• 96583-60-7 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide 
• 54215-05-3 2-[(1-oxido-1,2,4-benzotriazin-3-yl)amino]ethanol 
• 254-87-5 1,2,4-benzotriazene 
• 921933-23-5 cyclohexyl-(1-oxy-benzo[1,2,4]triazin-3-yl)-amine 

Relevant academic research and scientific papers

Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH3CN complex

Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H218OF·CH3CN in a fast, readily executed and high-yielding preparation of 1,2,4-benzotriazine 1,4-dioxides containing an 18O-label at the 4-oxide position.

Benzoazine mono-N-oxides and benzoazine 1,4 dioxides and compositions therefrom for the therapeutic use in cancer treatments

The present invention relates to a synergetistic composition comprising one or more benzoazine-mono-N-oxides, and one or more benzoazine 1,4 dioxides for use in cancer therapy. The invention also provides a range of novel 1,2,4 benzoazine-mono-N-oxides and related analogues. These can be used as potentiators of the cytotoxicity of existing anticancer drugs and therapies for cancer treatment.