2746-38-5Relevant academic research and scientific papers
TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond
Matcha, S. L.,Vidavalur, S.
, p. 1479 - 1486 (2021/10/26)
Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.
One-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via I2/TBHP-mediated oxidative C–N bond formation
Wu, Yachuang,Yang, Yifeng,Qi, Yinliang,Du, Shimei,Zhang, Yongsheng,Ding, Liang,Zhao, Yanfang
supporting information, p. 4216 - 4220 (2018/10/26)
A metal-free iodine/TBHP-mediated oxidative C–N bond formation for the one-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via cyclization has been developed. This reaction which is amenable to scale-up affords the corresponding products with good to excellent yields and tolerates a wide range of functional groups.
Efficient synthesis of 3-substituted 1,2,4-triazolo[4,3-a]pyridine by [bis(trifluroacetoxy)iodo]benzene-catalyzed oxidative intramolecular cyclization of heterocyclic hydrazones
Padalkar, Vikas S.,Patil, Vikas S.,Phatangare, Kiran R.,Umape, Prashant G.,Sekar
, p. 925 - 938 (2011/04/22)
A series of 1,2,4-triazolopyridines have been prepared by oxidative intramolecular cyclization of heterocyclic hydrazones with [bis(trifluroacetoxy) iodo]benzene. General applicability of this simple transformation was confirmed by synthesis of 1,2,4-triazolo[4,3-a]pyridine. The advantages of this protocol are the nontoxicity of catalyst and shorter reaction time to obtain good preparative yield.
A simple and efficient automatable one step synthesis of triazolopyridines from carboxylic acids
Wang, Ying,Sarris, Kathy,Sauer, Daryl R.,Djuric, Stevan W.
, p. 2237 - 2240 (2007/10/03)
Triazolopyridines can be rapidly and efficiently synthesized from a variety of carboxylic acids with 2-hydrazinopyridines in one simple step. The use of commercially available PS-PPh3 resin combined with microwave heating delivered the product
