2746-47-6

Usage

Type of Compound

Heterocyclic compound

Structure

Contains a triazolopyridine ring and a 3-(4-methylphenyl) substituent

Pharmaceutical drugs

Studied for its potential biological activities

Materials science

Investigated for its potential use in the field

Versatility

Range of potential applications in various fields

Upstream product

• 2824-70-6 2-(2-(4-mehtylbenzylidene)hydrazinyl)pyridine 
• 4930-98-7 pyrid-2-ylhydrazine 
• 274-80-6 [1,2,4]triazolo[4,3-a]pyridine 
• 624-31-7 4-tolyl iodide 
• 13939-06-5 molybdenum hexacarbonyl 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 110-86-1 pyridine 
• 104-87-0 4-methyl-benzaldehyde 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 5977-87-7 4-methyl-dithiobenzoic acid methyl ester 
• 109-09-1 2-chloropyridine 

Relevant academic research and scientific papers

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

Method for preparing 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis

The invention discloses a method for preparing a 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis. The method comprises the following steps: enabling a pyridine compound, sodium azide and a benzaldehyde compound to react suffici

Facile one pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclisation using DDQ

A facile and expedient one pot synthesis of N-fused 1,2,4-triazoles from 2-hydrazinopyridines or 2-hydrazinopyrazines and aldehydes is described via oxidative cyclization using DDQ as a safe and convenient oxidizing agent and polyethylene glycol as recyclable reaction medium. This protocol is effective toward various substrates having different functionalities. The easy recyclability of the reaction medium makes the process economic and potentially viable for commercial applications.

One-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via I2/TBHP-mediated oxidative C–N bond formation

A metal-free iodine/TBHP-mediated oxidative C–N bond formation for the one-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via cyclization has been developed. This reaction which is amenable to scale-up affords the corresponding products with good to excellent yields and tolerates a wide range of functional groups.

KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: Efficient one-pot synthesis of 1,2,4-triazolo[4,3-a] pyridines

A one-pot approach to substituted 1,2,4-triazolo[4,3-a]pyridines has been developed that is based on a KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines. This transition-metal-free procedure was highly efficient and shows good economical and environmental advantages.

[1,2,4]-triazol [4,3-a] pyridines compound and synthesis method thereof

The invention discloses a [1,2,4]-triazol [4,3-a] pyridines compound and a synthesis method thereof. The compound has a structure general formula shown as the formula (I), wherein R1 is selected fromaryl and heterocyclic groups; R2 is selected from hydrogen, alkyl, alkoxy, halogen or aryl. According to the synthesis method, alpha-ketonic acid and 2-hydrazinopyridine are used as raw materials; KIis used as a catalyst; Na2CO3 is used as alkali; TBHP is used as an oxidizing agent; 1,4-dioxane is used as a solvent; after a series of serial connection cyclization and decarboxylation aromatization, the [1,2,4]-triazol [4,3-a] pyridines compound is obtained. The [1,2,4]-triazol [4,3-a] pyridines compound is prepared under the condition of no transition metal and has the advantages that the reaction is efficient and fast; the conditions are mild; the substrate is simple and can be easily obtained; the applicability is wide; the reaction time is short; the yield is high, and the like; meanwhile, the post treatment of the reaction is simple and convenient; the harm to experiment operators is reduced; the environment-friendly effect is achieved; the green chemical requirements are met.

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio

A novel approach for the synthesis of imidazo and triazolopyridines from dithioesters

T3P-DMSO mediated desulfurative cyclization of in situ generated thioamides serves as an efficient and versatile method for the synthesis of imidazo[1,5-a]pyridines and [1,2,4]-triazolo[4,3-a]pyridines with good to excellent yields. Substrates such as 2-methylaminoquinoline and pyrazin-2-yl-methanamine also undergo the corresponding reactions at room temperature. This efficient protocol has several advantages such as mild conditions, short reaction time, operational simplicity and high yields.

Synthesis of 1,2,4-Triazoles, N-Fused 1,2,4-Triazoles and 1,2,4-Oxadiazoles via Molybdenum Hexacarbonyl-Mediated Carbonylation of Aryl Iodides

A convenient and efficient protocol has been developed for the synthesis of 1,2,4-triazoles, N-fused 1,2,4-triazoles and 1,2,4-oxadiazoles using molybdenum hexacarbonyl where, for the first time, molybdenum hexacarbonyl acts as a convenient and reliable s

Cu-catalysed direct C-H (hetero)arylation of [1,2,4]triazolo[4,3-a]pyridine to construct deep-blue-emitting luminophores

Cu-catalysed direct C-H (hetero)arylation of [1,2,4]triazolo[4,3-a]pyridine has been accomplished for the first time to streamline the synthesis of 3-aryl-[1,2,4]triazolo[4,3-a]pyridines for screening blue-emitting materials. On this basis, the photophysi