27465-68-5Relevant academic research and scientific papers
Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues
Guo, Zeng-Jun,Zhou, Kai,Cao, Yong-Xiao,Li, Yan,Zhang, San-Qi
, p. 1647 - 1651 (2012/11/07)
Six analogues of lacidipine, (E)-diethyl 4-(2-(3-amino)-3-oxoprop-1-enyl) phenyl-2, 6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates (compounds 1-6), were synthesized and their antihypertensive effects in spontaneously hypertensive rats were evaluated by
An efficient synthesis of 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid and some carbonyl derivatives of it and its 6-acetyl homologue
Sanchez,Mich,Huang
, p. 297 - 303 (2007/10/02)
Starting with 1,1-dimethoxy-2-propanone (1), 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5a) has been prepared in large quantities by a highly efficient, 4-step synthesis. This compound, along with its one carbon homologue, 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5b) has been reacted with several carbonyl derivative forming reagents to provide a series of side chains for β-lactams. Among these carbonyl derivatives are styrylamides which were prepared from Wittig and Horner-Emmons reagents. The preparation of the phosphonium salts and phosphonate esters is also described.
Condensed pyrrolinone derivatives, their production and use
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, (2008/06/13)
The compound of the formula STR1 wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH CH--CH CH--, --S--(CH 2) l --S--(l is an integer of 1 to 3), --N CH--CH N-- o
