27467-92-1

Usage

Derived from

Pyridine

Common uses

Antifungal agent in pharmaceutical and personal care products

Anti-fungal activity

Strong against a wide range of pathogenic fungi

Mechanism of action

Inhibits the synthesis of ergosterol, an essential component of fungal cell membranes, leading to cell death

Broad-spectrum antifungal activity

Valuable in the treatment of various fungal infections, including athlete's foot and ringworm

Potential use

Control of fungal diseases in crops in agricultural applications

Upstream product

• 31784-71-1 5-chlorothiazolo[5,4-b]pyridin-2-amine 
• 78909-78-1 2-(β-Cyanoethyl)thio-3-amino-6-chloropyridine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 62476-56-6 3-amino-2,6-dichloropyridine 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 101560-81-0 5-chloro-2-phenylthiazolo[5,4-b]pyridine 
• 103566-37-6 6-chloro-2-(2-nitro-phenylsulfanyl)-[3]pyridylamine 
• 103646-12-4 6-chloro-2-(2,4-dinitro-phenylsulfanyl)-[3]pyridylamine 
• 53688-15-6 6-chloro-3,3-dimethyl-2-phenyl-3H-pyrido[2,3-b][1,4]thiazine 
• 70183-02-7 1,2-Dioxo-3a-ethyl-7-chlorooxazolidino<3,2-f>pyrido<2,3-b>-1,4-thiazine 
• 31089-60-8 6-chloro-2-phenyl-1H-pyrido[2,3-b][1,4]thiazine-3-carboxylic acid ethyl ester 
• 49851-46-9 6-chloro-2-(2-fluoro-phenyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-2-ol 
• 49851-49-2 6-chloro-2-(2-fluoro-phenyl)-3H-pyrido[2,3-b][1,4]thiazine 
• 49851-47-0 2-(2-bromo-phenyl)-6-chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-2-ol 
• 49851-50-5 2-(2-bromo-phenyl)-6-chloro-3H-pyrido[2,3-b][1,4]thiazine 
• 27468-01-5 6-chloro-2-(4-nitro-phenyl)-3H-pyrido[2,3-b][1,4]thiazine 
• 49851-51-6 6-chloro-2-(2,4-dimethoxy-phenyl)-3H-pyrido[2,3-b][1,4]thiazine 
• 37489-37-5 2-Chlor-6-amino-pyrido<2,3-6>-<1,4>-thiazin 
• 27467-99-8 2-(6-chloro-3H-pyrido[2,3-b][1,4]thiazin-2-yl)-5-ethoxy-phenol 

Relevant academic research and scientific papers

THE FIRST BRANCHED BENZOXAZINOPHENOTHIAZINE RING SYSTEM AND ITS AZA-ANALOGUES

The synthesis of a branched benzoxazinophenotiazine heterocycle is described.The parent compound benzo-benzoxazinophenothiazine (12), was obtained from 2,3-dichloro-1,4-naphthoquinone (6), 2-aminophenol and 2-aminothiophenol.Monoaza-, diaza- and triaza- analogues of this novel heterocycle were also synthesized.The parent compounds, 16-oxa-15-thia-4,5,10,14-tetraazabenzopentaphene (18) and 16-oxa-15-thia-4,5,10,14-tetraazabenzopentaphene (22, R=H) were also synthesized as well as 4-amino-16-oxa-15-thia-4,5,10,14-tetraazabenzopentaphene (24).They are intensely coloured high-melting solids suitable for application as pigments.Their ease of reduction with Na2S2O4 and the ready oxidation of the reduced compounds to applicability also as vat dyes.

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives

A series of novel thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. These compounds showed potent antifungal activities in vitro and in vivo. In particular, (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4- difluorophenyl)-1-(1H-1,2,4-triazol-l-yl)-2-butanol (12g; ER-30346) showed potent and well-balanced in vitro activities and potent in vivo efficacy, and had a good safety profile.

INVESTIGATION OF NITROGEN- AND SULFUR-CONTAINING HETEROCYCLES. 39. REACTIONS OF 2-MERCAPTO-3-UREIDO- AND 2-MERCAPTO-3-AMINOPYRIDINES WITH β-HALO CARBONYL COMPOUNDS. SYNTHESIS OF 6-OXO DERIVATIVES OF PYRIDOTHIAZEPINES

The reaction of 2-mercapto-3-ureido- and 2-mercapto-3-aminopyridines with β-halo derivatives of carbonyl compounds (ketones, acids, and aldehydes) and with acrylonitrile proceeds not only via the mercapto group but also via the amino group, as a result of