274680-24-9Relevant academic research and scientific papers
Enantioselective Reductive Divinylation of Unactivated Alkenes by Nickel-Catalyzed Cyclization Coupling Reaction
Peng, Xuejing,Qiao, Jin-Bao,Shu, Xing-Zhong,Yao, Qi-Wei,Zhang, Ya-Qian,Zhao, Zhen-Zhen
supporting information, p. 12961 - 12967 (2021/09/03)
Catalytic asymmetric dicarbofunctionalization of tethered alkenes has emerged as a promising tool for producing chiral cyclic molecules; however, it typically relies on aryl-tethered alkenes to form benzene-fused compounds. Herein, we report an enantioselective cross-electrophile divinylation reaction of nonaromatic substrates, 2-bromo-1,6-dienes. The approach thus offers a route to new chiral cyclic architectures, which are key structural motifs found in various biologically active compounds. The reaction proceeds under mild conditions, and the use of chiral t-Bu-pmrox and 3,5-difluoro-pyrox ligands resulted in the formation of divinylated products with high chemo-, regio-, and enantioselectivity. The method is applicable for the incorporation of chiral hetero- and carbocycles into complex molecules.
Suppressed β-hydride elimination in palladium-catalyzed cascade cyclization-coupling reactions: An efficient synthesis of 3-arylmethylpyrrolidines
Lee, Chi-Wan,Oh, Kyung Seok,Kim, Kwang S.,Ahn, Kyo Han
, p. 1213 - 1215 (2007/10/03)
(formula presented) A novel type of palladium-catalyzed cascade cyclization-coupling reaction that proceeds with suppressed β-hydride elimination has been found. One of the N-sulfonyl oxygens is suggested to coordinatively stabilize an alkylpalladium inte
