274686-27-0

Upstream product

• 97589-53-2 (S)-2,2,2-triuoro-N-(3-methyl-1-oxo-1-phenylbutan-2-yl)acetamide 
• 100-58-3 phenylmagnesium bromide 
• 79069-51-5 (S)-N-tert-butoxycarbonylvalinal 
• 111060-66-3 L-dibenzylvalinal 
• 72-18-4 L-valine 
• 56236-38-5 N-trifluoroacetyl-L-valyl chloride 
• 111060-51-6 (S)-benzyl 2-(dibenzylamino)-3-methylbutanoate 
• 111060-54-9 N,N-dibenzylvalinol 

Downstream Products

• 757243-39-3 (S)-(1R,2S)-3-methyl-1-phenyl-2-(pyrrolidin-1-yl)butyl ethanetioate 

Relevant academic research and scientific papers

SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein L1 is an optionally substituted C1-6 alkylene group or the like, L2 is a single bond or the like, L3 is a single bond or the like, R1, R2, and R3 are each independently an optionally substituted C1-4 alkyl group or the like, R4 is a hydrogen atom or the like, and R5 is a hydrogen atom or the like.

The application of chiral amino thiols as catalysts in the enantioselective addition of diethylzinc to aldehydes

Starting from (S)-(-)-valine, a series of new chiral amino thiol and corresponding thioacetate ligands were prepared in an efficient manner and applied in the asymmetric diethylzinc addition to aldehydes with excellent enantioselectivity as high as 99% ee

N-(Trifluoroacetyl)-α-amino Acid Chlorides as Chiral Reagents for Friedel-Crafts Synthesis

Chiral N-(trifluoroacetyl)-α-amino acid chlorides unergo Friedel-Crafts reaction with benzene and 1,2-dimethoxybenzene under mild conditions commonly with complete (>99percent) preservation of configurational identity.The resultant (trifluoroacetyl)amino ketones may be deoxygenated with Et3SiH or H2/Pd-C in acidic media to the corresponding N-(trifluoroacetyl)-β-arylalkylamines likewise without loss of configurational purity.