274691-28-0

Basic information

• Product Name: 2,4-dichloro-6-fluoro-3-phenylquinoline
• Synonyms: Quinoline, 2,4-dichloro-6-fluoro-3-phenyl-
• CAS NO: 274691-28-0
• Molecular Formula: C₁₅H₈Cl₂FN
• Molecular Weight: 292.1351
• Mol File: 274691-28-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 366.1°C at 760 mmHg
• Flash Point: 175.2°C
• Density: 1.39g/cm³
• Vapor Pressure: 3.16E-05mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: 2,4-dichloro-6-fluoro-3-phenylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-6-fluoro-3-phenylquinoline(274691-28-0)
• EPA Substance Registry System: 2,4-dichloro-6-fluoro-3-phenylquinoline(274691-28-0)

Safety Data

• Hazardous Substances Data: 274691-28-0(Hazardous Substances Data)

Upstream product

• 83-13-6 diethyl 2-phenylmalonate 
• 371-40-4 4-fluoroaniline 
• 2613-89-0 phenylmalonic acid 
• 1259521-33-9 3-(4-fluorophenylamino)-3-oxo-2-phenylpropanoic acid 
• 1259521-32-8 ethyl 3-(4-fluorophenylamino)-3-oxo-2-phenylpropanoate 
• 144603-08-7 6-fluoro-3-phenylquinoline-2,4-diol 

Downstream Products

• 1259521-36-2 2-ethyl-6-fluoro-4-(methylthio)-3-phenylquinoline 
• 1259521-62-4 2-ethyl-6-fluoro-4-methoxy-3-phenylquinoline 
• 1259521-35-1 2-(1-bromoethyl)-6-fluoro-4-(methylthio)-3-phenylquinoline 
• 1259521-37-3 2-(1-(6-fluoro-4-(methylthio)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione 
• 1308264-35-8 C₂₆H₁₉FN₂O₄S 
• 1259521-38-4 1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethanamine 
• 1259521-29-3 4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile 
• 1259523-31-3 4-amino-6-(((1S)-1-(6-fluoro-4-(methylsulfonyl)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile 
• 1259521-61-3 2-(1-bromoethyl)-6-fluoro-4-methoxy-3-phenylquinoline 
• 1259521-63-5 2-(1-(6-Fluoro-4-methoxy-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione 
• 1259521-64-6 2-(1-(6-fluoro-4-hydroxy-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione 
• 1308264-55-2 C₁₈H₁₇FN₂O 
• 1308272-31-2 C₁₇H₁₅FN₂O 
• 1259521-65-7 4-Amino-6-(1-(6-fluoro-4-methoxy-3-phenylquinolin-2-yl)ethylamino)pyrimidine-5-carbonitrile 

Relevant articles and documents

Synthesis and SAR study of potent and selective PI3Kδ inhibitors

2,3,4-Substituted quinolines such as (10a) were found to be potent inhibitors of PI3Kδ in both biochemical and cellular assays with good selectivity over three other class I PI3K isoforms. Some of those analogs showed favorable pharmacokinetic properties.