27471-36-9Relevant academic research and scientific papers
Preparation method of apixaban intermediate
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Paragraph 0039-0041, (2019/08/30)
The invention relates to a preparation method of an apixaban intermediate. The preparation method of the apixaban intermediate I comprises the following steps: p-chloroaniline, used as a raw material,and halide undergo an amidation and cyclization reaction under an alkaline condition to obtain 1-(4-chlorophenyl)piperidine-2-one, the 1-(4-chlorophenyl)piperidine-2-one and phosphorus pentachlorideundergo dichloro substitution, condensation-elimination and morpholine substitution to obtain the apixaban intermediate I. The method has the advantages of low cost, high reaction yield, and suitableness for industrial operation.
Preparation method of apixaban and intermediate thereof
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Paragraph 0112-0116, (2019/08/06)
The invention relates to a preparation method of apixaban (an antithrombotic drug) and a related intermediate, The preparation method comprises the specific steps as follows: carrying out amidation-cyclization integrated reaction on p-nitroaniline, which
New synthetic routes for N-substituted 1,n-diamines. II. Synthesis of selectively N-substituted tetra- and pentamethylenediamines from ω-alkanoic acid derivatives
Ramírez, María A.,Corona, María V.,Ortiz, Gisela,Salerno, Alejandra,Perillo, Isabel A.,Blanco, María M.
supporting information; experimental part, p. 1466 - 1468 (2011/06/10)
A new approach for the synthesis of selectively N-substituted tetra- and pentamethylenediamines 1 (n = 4,5) is described. The method uses N-substituted ω-haloalkanamides 2 as precursors and involves the microwave-promoted conversion into ω-azidocarboxamides 3 and later the reduction of both azido and carboxamide groups with diborane.
