27472-36-2

Basic information

• Product Name: (1H-PYRROL-2-YL)-METHANOL
• Synonyms: 2-HydroxyMethylpyrrole;1H-Pyrrole-2-Methanol;2-Methylolpyrrole;Pyrrole-2-Methanol;Pyrrolyl-2-carbinol
• CAS NO: 27472-36-2
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.1152
• Product Categories: Heterocycles
• Mol File: 27472-36-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 117.5-118 °C
• Boiling Point: 246.325 °C at 760 mmHg
• Flash Point: 102.774 °C
• Appearance: /
• Density: 1.191 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.58
• PKA: 14.02±0.10(Predicted)
• CAS DataBase Reference: (1H-PYRROL-2-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-PYRROL-2-YL)-METHANOL(27472-36-2)
• EPA Substance Registry System: (1H-PYRROL-2-YL)-METHANOL(27472-36-2)

Safety Data

• Hazardous Substances Data: 27472-36-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 27472-36-2 differently. You can refer to the following data:
1. (1H-pyrrol-2-yl)Methanol is used in a new synthesis of porphobilinogen and other trisubstituted pyrroles for photodynamic therap.
2. Used in a new synthesis of porphobilinogen and other trisubstituted pyrroles for photodynamic therapy.

InChI:InChI=1/C5H7NO/c7-4-5-2-1-3-6-5/h1-3,6-7H,4H2

Upstream product

• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 116967-16-9 1-hydroxymethyl-2-pyrrolaldehyde 
• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 504434-02-0 N-benzyl-1H-pyrrole-2-carboxamide 
• 634-97-9 pyrrole-2-carboxyl acid 
• 221318-29-2 2-<(2-hydroxymethylphenyl)thiomethyl>-5-trifluoroacetyl-1H-pyrrole 
• 221318-28-1 2-<(2-hydroxymethylphenyl)thiomethyl>-5-trichloroacetyl-1H-pyrrole 
• 221318-27-0 2-<(2-hydroxymethylphenyl)thiomethyl>-1H-pyrrole-2-carboxyaldehyde 
• 221318-25-8 2-<(2-acetoxymethylphenyl)thiomethyl>-1H-pyrrole 
• 221318-24-7 2-<(2-hydroxymethylphenyl)thiomethyl>-1H-pyrrole 
• 101-60-0 porphyrin 
• 221318-23-6 2-<(2-methoxycarbonylphenyl)thiomethyl>-1H-pyrrole 
• 4396-11-6 calix[4]pyrrole 
• 93091-59-9 2-bromoporphin 

Relevant articles and documents

-

-

Chemoselective transfer hydrogenation of aromatic and heterocyclic aldehydes by green chemically prepared cobalt oxide nanoparticles

A new surfactant (quercetin) assisted hydrothermal method is used for the preparation of phase pure cobalt oxide (Co3O4) nanoparticles (Nps). The quercetin acted well as surfactant in producing size controlled Nps. The produced Nps were extensively characterized by various techniques to reveal its chemical composition, structure, morphology, size and thermal behavior. The main objective of the study is to employ the prepared material as heterogeneous catalyst for hydrogenation of therapeutically important aldehydes. The capability of the catalyst is appear to be good, since the yield of alcohols from structurally different aldehydes is adequate with short period of time. Also the catalyst is recyclable, stable, no need of addition of ligands for activation and environmentally benign.

Selective mono-reduction of pyrrole-2,5 and 2,4-dicarboxylates

Pyrrole-2,5-dicarboxylates were rapidly and selectively reduced to the corresponding mono-alcohol using 3 eq of diisobutylaluminum hydride at 0°C. Pyrrole-2,4-dicarboxylate showed the same reactivity; however, the selectivity decreased with pyrrole-3,4-dicarboxylate. When the nitrogen atom of the pyrrole-2,5-dicarboxylate is protected with a benzyl group, selective mono-reduction does not occur. Considering that furan-2,5-dicarboxylates did not give the corresponding mono-alcohol under the same conditions, the unprotected nitrogen atom of pyrrole apparently plays an important role in this selective mono-reduction.