27473-61-6

Basic information

• Product Name: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE
• Synonyms: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE;AKOS 146;S.2-712;Spiro[indane-2,4'-imidazolidine]-2',5'-dione;1',3'-Dihydrospiro[iMidazolidine-4,2'-indene]-2,5-dione
• CAS NO: 27473-61-6
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.21
• Mol File: 27473-61-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 260-267 °C(Solv: ethanol (64-17-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.4g/cm³
• PKA: 10.29±0.20(Predicted)
• CAS DataBase Reference: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE(27473-61-6)
• EPA Substance Registry System: 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE(27473-61-6)

Safety Data

• Hazardous Substances Data: 27473-61-6(Hazardous Substances Data)

Usage

General Description

1',3'-dihydro-spiro(imidazolidine-4,2'-(2H)indene)-2,5-dione is a chemical compound with a spiro-indene structure. It is a heterocyclic compound containing an imidazolidine ring and a diketone functionality. 1',3'-DIHYDRO-SPIRO(IMIDAZOLIDINE-4,2'-(2H)INDENE)-2,5-DIONE may have potential pharmacological properties due to its unique structure, and it could be used in the development of new drugs or as a building block for organic synthesis. However, further research is needed to fully understand its potential uses and properties.

Upstream product

• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 615-13-4 2-indanone 
• 773837-37-9 sodium cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 27473-62-7 2-amino-2,3-dihydro-1H-indene-2-carboxylic acid 
• 1401008-12-5 C₂₇H₂₄F₆N₄O₄ 
• 1210815-86-3 5'-bromo-1-(4-methoxybenzyl)-3-methyl-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione 
• 1210815-85-2 5'-bromo-1-(4-methoxybenzyl)-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione 
• 1398717-91-3 (S)-2-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)-2,3-dihydro-1H-indene-2-carboxamide 
• 1398718-54-1 (S)-tert-butyl 2-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-2,3-dihydro-1H-inden-2-ylcarbamate 
• 33584-66-6 (+/-)-5'-nitro-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione 
• 1240303-22-3 C₁₁H₉N₃O₄ 
• 199330-64-8 2-amino-indane-2-carboxylic acid methyl ester hydrochloride 
• 71066-00-7 2-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid 
• 905278-33-3 1,3-dibenzyl-4-hydroxyspiro(imidazolidin-5,2'-indane)-2-one 
• 905278-48-0 1,3-dibenzyl-4,9-dihydrobenzo[f]benzimidazol-2-one 
• 905278-41-3 3-benzyl-4-hydroxyspiro(imidazolidin-5,2'-indane)-2-one 
• 905278-23-1 3-benzylspiro(imidazolidin-5,2'-indane)-2,4-dione 

Relevant articles and documents

-

-

ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS

The present invention is directed to aliphatic spirolactam derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical\compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

PIPERIDINE CARBOXAMIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS

The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also d