2748-32-5

Upstream product

• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 209973-90-0 4-hydroxy-2-oxo-3-(1'-oxo-3'-phenylprop-2'-enyl)-2H-[1]-benzopyran 
• 57339-60-3 3-cinnamoyl-4-hydroxy-2H-chromen-2-one 

Downstream Products

• 2549-24-8 1-benzoyl-3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5-phenyl-4,5-dihydro-1H-pyrazole 
• 836678-29-6 3-(1-hydrazinoacetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-chromen-2-one 
• 836678-27-4 3-(1-chloroacetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-chromen-2-one 

Relevant academic research and scientific papers

The role of the intermolecular π···π interactions in the luminescence behavior of novel coumarin-based pyrazoline materials

Novel nine coumarin-based pyrazolines have been synthesized and fully characterized in search of new fluorescent compounds for design stimuli-responsive chromic materials. All reported compounds behave as highly fluorescent materials, both in solution and

3-Substituted-4-hydroxycoumarin as a new scaffold with potent CDK inhibition and promising anticancer effect: Synthesis, molecular modeling and QSAR studies

A new series of 3-substituted-4-hydroxycoumarin derivatives was designed, synthesized, and evaluated for CDK inhibiting and anticancer activities. All the synthesized target compounds showed remarkably high affinity and selectivity towards CDK1B, compared to flavopiridol, with Ki values in the low nanomolar range (Ki?=?0.35–0.88?nM). Most of them elicited considerable inhibiting effect against CDK9T1 (Ki?=?3.26–23.45?nM). Moreover, all the target compounds were tested in vitro against eighteen types of human tumor cell lines. The hydrazone 3a, N-phenylpyrazoline derivative 6b and 2-aminopyridyl-3-carbonitrile derivative 8c were the most potent anticancer agents against MCF-7 breast cancer cell line (IC50?=?0.21, 0.21 and 0.23?nM, respectively). The target compounds 3a, 6b and 8c were further evaluated in MCF-7 breast cancer mouse xenograft model and showed in vivo efficacy at 10?mg/kg dose. The docking study confirmed a unique binding mode in the active site of CDK1B with better score than flavopiridol. Quantitative structure activity relationship study was done and revealed a highly predictive power R2 of 0.81.

Synthesis of some biologically active pyrazole, thiazolidinone, and azetidinone derivatives

Pyrazole, thiazolidinone, and azetidinone derivatives were synthesized from chalcones of 4-hydroxycoumarin. The structures of all the synthesized compounds were confirmed on the basis of spectral and analytical data. The compounds were screened in vitro for their antibacterial activity against various bacterial strains.