27482-95-7

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 123-72-8 butyraldehyde 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 110-62-3 pentanal 

Downstream Products

• 148171-64-6 (2S)-N-(S)-α-methylbenzyl-2-propyl-4-piperidinone 
• 148171-65-7 (2S)-4-(1,3-dithiolane-2-yl)-N-(S)-α-methylbenzyl-2-propylpiperidine 
• 19302-34-2 (S)-(-)-N-(1-phenylethyl)butylamine 
• 348608-03-7 (+)-N-[(R)-α-methylbenzyl]-hept-1-ene-4-amine 
• 628729-62-4 (R)-(+)-N-butyl-N-(α-phenylethyl)amine 
• 348608-06-0 (+)-N-allyl,N-[(R)-α-methylbenzyl]-hept-1-ene-4-amine 
• 1380114-15-7 C₂₀H₂₄N₂O 
• 348608-12-8 2R-(+)-4,5-didehydro-N-[(R)-α-methylbenzyl]-2-propyl-piperidine 

Relevant academic research and scientific papers

Enantioselective Formation of 2-Azetidinones by Ring-Assisted Cyclization of Interlocked N-(α-Methyl)benzyl Fumaramides

The synthesis of optically active interlocked and non-interlocked 2-azetidinones by intramolecular cyclization of N-(α-methyl)benzyl fumaramide [2]rotaxanes is described. Two different strategies of asymmetric induction were tested in which the chiral gro

Double stereodifferentiation in the catalytic asymmetric aziridination of imines prepared from α-chiral amines

The catalytic asymmetric aziridination of imines and diazo compounds (AZ reaction) mediated by boroxinate catalysts derived from the VANOL and VAPOL ligands was investigated with chiral imines derived from five different chiral, disubstituted, methyl amines. The strongest matched and mismatched reactions with the two enantiomers of the catalyst were noted with disubstituted methyl amines that had one aromatic and one aliphatic substituent. The synthetic scope for the AZ reaction was examined in detail for α-methylbenzyl amine for cis-aziridines from α-diazo esters and for trans-aziridines from α-diazo acetamides. Optically pure aziridines could be routinely obtained in good yields and with high diastereoselectivity and the minor diastereomer (if any) could be easily separated. The matched case for cis-aziridines involved the (R)-amine with the (S)-ligand, but curiously, for trans-aziridines the matched case involved the (R)-amine with the (R)-ligand for imines derived from benzaldehyde and n-butanal, and the (R)-amine with the (S)-ligand for imines derived from the bulkier aliphatic aldehydes pivaldehyde and cyclohexane carboxaldehyde.

Regio- and stereoselective dirhodium(II)-catalysed intramolecular C-H insertion reactions of α-diazo-α-(dialkoxyphosphoryl)acetamides and -acetates

α-Diazo-α-(dialkoxyphosphoryl)acetates and -acetamides afforded α-(dialkoxyphosphoryl)lactones and lactams, respectively, in moderate to high yields through dirhodium(II)-catalysed intramolecular carbon-hydrogen insertion reactions. In the case of α-diazo