2749-84-0Relevant articles and documents
Reactivity and chemoselectivity of allenes in Rh(I)-catalyzed intermolecular (5 + 2) cycloadditions with vinylcyclopropanes: Allene-mediated rhodacycle formation can poison Rh(I)-catalyzed cycloadditions
Hong, Xin,Stevens, Matthew C.,Liu, Peng,Wender, Paul A.,Houk
, p. 17273 - 17283 (2015)
Allenes are important 2π building blocks in organic synthesis and engage as 2-carbon components in many metal-catalyzed reactions. Wender and co-workers discovered that methyl substituents on the terminal allene double bond counterintuitively change the reactivities of allenes in [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2) cycloadditions with vinylcyclopropanes (VCPs). More sterically encumbered allenes afford higher cycloadduct yields, and such effects are also observed in other Rh(I)-catalyzed intermolecular cycloadditions. Through density functional theory calculations (B3LYP and M06) and experiment, we explored this enigmatic reactivity and selectivity of allenes in [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2) cycloadditions with VCPs. The apparent low reactivity of terminally unsubstituted allenes is associated with a competing allene dimerization that irreversibly sequesters rhodium. With terminally substituted allenes, steric repulsion between the terminal substituents significantly increases the barrier of allene dimerization while the barrier of the (5 + 2) cycloaddition is not affected, and thus the cycloaddition prevails. Computation has also revealed the origin of chemoselectivity in (5 + 2) cycloadditions with allene-ynes. Although simple allene and acetylene have similar reaction barriers, intermolecular (5 + 2) cycloadditions of allene-ynes occur exclusively at the terminal allene double bond. The terminal double bond is more reactive due to the enhanced d-π backdonation. At the same time, insertion of the internal double bond of an allene-yne has a higher barrier as it would break π conjugation. Substituted alkynes are more difficult to insert compared with acetylene, because of the steric repulsion from the additional substituents. This leads to the greater reactivity of the allene double bond relative to the alkynyl group in allene-ynes.
Organometal-mediated synthesis of conjugated allenynes, allenediynes, vinylallenes and diallenes
Ruitenberg, K.,Kleijn, H.,Westmijze, H.,Meijer, J.,Vermeer, P.
, p. 405 - 409 (2007/10/02)
An extensive study of the reactivity of organometallic reagents R3M (R3 = 1-alkenyl, 1-alkynyl, 3-alken-1-ynyl, 1,3-alkadiynyl or 1,2-alkadienyl; M = Li, MgCl, ZnCl, Cu, Ag) towards R1R2C=C=CH-X (1) and R1R2C(X)-CCH (4) is described.High yields of R1R2C=C=CH=R3 (2) have been obtained by reaction of 1 (X = Br) with R3-M (M = MgCl, ZnCl or Cu1/2Li1/2) using Pd4 as catalyst.Similarly, pure 2 have been obtained by the Pd4-catalyzed reaction of 4 (X = Br, OAc, OS(O)Me, OSO2Me, OP(O)(OEt)2) with R3-M (M = MgCl, ZnCl, Zn1/2, Cu, Cu1/2Li1/2, Ag or Ag1/2Li1/2).In some reactions with R3-Cu, compounds 4 were cnverted into 2 in the absence of the palladium catalyst.
ALLENYLCOPPER(I) COMPOUNDSl SUITABLE REAGENTS FOR THE SYNTHESIS OF ALLENYNES
Ruitenberg, K.,Meijer, J.,Bullee, R. J.,Vermeer, P.
, p. 267 - 271 (2007/10/02)
Allenylcopper(I) compounds react smoothly and highly regioselectively with 1-iodo-1-alkynes to give allenynes in excellent yields.
