274902-12-4Relevant academic research and scientific papers
Stereoselective synthesis of α-alkylidene- and substituted alkylidene- γ-lactones
?astulík, Jakub,Mazal, Ctibor
, p. 2741 - 2744 (2007/10/03)
Cross-coupling reactions of (E)- and (Z)-tosylates of α- hydroxymethylene-γ-butyrolactone with aryl, heteroaryl, alkyl, and alkynylzinc chlorides under Pd(PPh3)4 catalysis were found to be a suitable synthetic method for stereoselective preparation of α-alkylidene- and substituted alkylidene-γ-lactones. The reactions, conducted under mild conditions, proceed with high stereoselectivity and moderate yields. (C) 2000 Elsevier Science Ltd.
