274911-01-2Relevant academic research and scientific papers
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones
Nacro, Kassoum,Bienfait, Bruno,Lewin, Nancy E.,Blumberg, Peter M.,Marquez, Victor E.
, p. 653 - 655 (2000)
New synthetic diacylglycerols (DAGs) with equivalent branched acyl chains were compared with commercially available DAGs as PK-C ligands. The results support the view that there is a minimal lipophilic requirement provided by the equivalent acyl groups th
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P)
Nacro,Sigano,Yan,Nicklaus,Pearce,Lewin,Garfield,Blumberg,Marquez
, p. 1892 - 1904 (2007/10/03)
A small, focused combinatorial library encompassing all possible permutations of acyl branched alkyl chains - small and large, saturated and unsaturated - was generated from the active diacylglycerol enantiomer (S-DAG) to help identify the analogue with t
