274914-52-2

Upstream product

• 163594-20-5 (2S)-benzyl-3-methoxycarbonylmethyl-Δ³-4-triflyloxy-N-(PhF)prolinate 
• 274914-46-4 4-furan-3-yl-3-methoxycarbonylmethyl-1-(9-phenyl-9H-fluoren-9-yl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis and pharmacology of new enantiopure Δ3-4-arylkainoids

Seven Δ3-4-arylkainoids possessing various 4-position aromatic and heteroaromatic groups were synthesized and their apparent affinities were measured in order to explore the influences of 4-position electron density and stereochemistry on receptor affinity and specificity. Kainoids 1a-f were shown to be selective agonists at the NMDA receptor and the electron rich furanyl and thienyl analogues exhibited the highest affinities. Naphthylkainoid 1g proved to be a nonselective antagonist at the iGluRs. (C) 2000 Elsevier Science Ltd. All rights reserved.