274915-17-2Relevant academic research and scientific papers
Synthesis and bladder smooth muscle relaxing properties of substituted 3-amino-4-aryl-(and aralkyl-)cyclobut-3-ene-1,2-diones
Butera, John A.,Jenkins, Douglas J.,Lennox, Joseph R.,Sheldon, Jeffrey H.,Norton, N. Wesley,Warga, Dawn,Argentieri, Thomas M.
, p. 2495 - 2501 (2007/10/03)
We have reported on the design, synthesis, and biological characterization of (R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-3- ethyl-benzonitrile (1),1 a novel, potent, and selective adenosine 5′-triphosphate-sensitive
4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
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, (2008/06/13)
4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having the Formula (I): wherein R1, R2, R3, R4, R5, A and W are as defined in the specification which compounds relaxes smooth muscles.
