27493-26-1Relevant articles and documents
A chiral bis-L - leucine hydrochloride preparation and synthetic method
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Paragraph 0080-0020, (2017/08/25)
The invention discloses a preparation method of chiral double L-leucine hydrochloride. The chiral double L-leucine hydrochloride has a chemical formula shown in the description; a synthesis method of the chiral double L-leucine hydrochloride comprises the following steps: weighing 0.03 mol of L-leucine (3.9354 g) into a 100 ml round-bottom flask; adding 40 ml of absolute methanol into L-leucine, performing stirring to ensure that L-leucine dissolves in absolute methanol and obtain a solution I; weighing 0.01 mol of CuCl2.2H2O (1.7048 g) into the solution to obtain a solution II; heating the solution II for a 48 hours' reflux reaction; after the reaction, and filtering a reaction solution when the reaction solution is hot to obtain a saturated solution, so that a filtrate naturally volatilizes, and green crystals are separated out after two days. The chiral double L-leucine hydrochloride has good catalytic performance in a nitrile silicification reaction of benzaldehyde, and has the yield rate of being as high as 75%.
