27493-61-4

Basic information

• Product Name: H-VAL-ALA-OH
• Synonyms: VAL-ALA;H-VAL-ALA-OH;L-VALYL-L-ALANINE;L-Val-L-Ala-OH;N-L-Valyl-L-alanine;N-Valylalanine;Val-Ala-OH;(S)-2-((S)-2-AMino-3-MethylbutanaMido)propanoic acid
• CAS NO: 27493-61-4
• Molecular Formula: C₈H₁₆N₂O₃
• Molecular Weight: 188.22
• Mol File: 27493-61-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 401.8 °C at 760 mmHg
• Flash Point: 196.8 °C
• Appearance: /
• Density: 1.134 g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: -15°C
• CAS DataBase Reference: H-VAL-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-VAL-ALA-OH(27493-61-4)
• EPA Substance Registry System: H-VAL-ALA-OH(27493-61-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 27493-61-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C8H16N2O3/c1-4(2)6(9)7(11)10-5(3)8(12)13/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 68858-20-8 Fmoc-Val-OH 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 55739-16-7 Z-L-Val-L-Ala-OEt 
• 349-00-8 N-trifluoroacetyl-L-valine 
• 24601-74-9 (S)-4-isopropyloxazolidine-2,5-dione 
• 41445-88-9 Z-Val-OCO₂ⁱBu 
• 118234-89-2 Z-(S)-Val-(S)-Ala-OBzl 
• 47094-07-5 (S)-2-((S)-2-Amino-3-methyl-butyrylamino)-propionic acid benzyl ester 
• 17445-33-9 (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)propanoic acid 
• 6491-36-7 N-(D-α-bromo-isovaleryl)-L-alanine 
• 1478-88-2 N-(N-trifluoroacetyl-L-valyl)-L-alanine methyl ester 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Downstream Products

• 338-69-2 D-Alanine 
• 72-18-4 L-valine 
• 77257-03-5 α-²H-(S)-valine 
• 15136-26-2 (3S,6S)-3-methyl-6-(1-methylethyl)piperazine-2,5-dione 
• 1343407-91-9 allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1- oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 

Relevant articles and documents

SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Synthesis and NMR elucidation of pentacycloundecane-derived hydroxy acid peptides as potential anti-HIV-1 agents

The synthesis and NMR elucidation of eight novel peptides incorporating the pentacycloundecane (PCU)-derived hydroxy acid are reported. The PCU cage amino acids were synthesized as racemates and the incorporation of the PCU-derived hydroxy acid with natural (S)-amino acids produced inseparable diastereomeric peptides. A series of overlapping signals from the cage and that of the peptide side chain was observed in the 1H- and 13C-NMR spectra, complicating the elucidation thereof. Two-dimensional NMR techniques proved to be a very useful tool in overcoming these difficulties. These compounds are potential HIV protease inhibitors.

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.