27512-24-9

Upstream product

• 75-21-8 oxirane 
• 109-77-3 malononitrile 
• 107-07-3 2-chloro-ethanol 
• 106412-04-8 2-benzoyloxyethylmalononitrile 

Downstream Products

• 98061-56-4 2-benzamido-4,5-dihydro-3-furancarbonitrile 
• 106412-04-8 2-benzoyloxyethylmalononitrile 
• 486430-11-9 tetrahydro-2-imino-3-(3-oxo-1-phenylbutyl)-3-furancarbonitrile 
• 860302-93-8 2-(4-chlorobenzamido)-4,5-dihydro-3-furancarbonitrile 
• 486430-30-2 2,3,3a,4,5,7a-hexahydro-7a-methoxy-6-methyl-4-phenylfuro[2,3-b]pyridine-3a-carbonitrile 
• 486430-27-7 7a-ethoxy-2,3,3a,4,5,7a-hexahydro-6-methyl-4-phenylfuro[2,3-b]pyridine-3a-carbonitrile 
• 27512-26-1 2-oxotetrahydrofuran-3-carbonitrile 
• 1017244-48-2 2-[(4-chlorophenyl)amino]-4,5-dihydro-3-furancarbonitrile 
• 1017244-90-4 4-cyano-3,4-dihydro-6-phenyl-2H-pyran-4-carboxamide 
• 1017244-92-6 6-(4-chlorophenyl)-4-cyano-3,4-dihydro-2H-pyran-4-carboxamide 
• 121743-74-6 2,3-dihydro-6-methylfuro[2,3-b]pyridine 
• 81108-69-2 2-Phenyl-6,7-dihydro-furo[2,3-d]pyrazolo[1,5-a]pyrimidin-8-ylamine 
• 133036-80-3 ethyl N-2-(3-cyano-4,5-dihydrofuryl)carbamate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

HETEROCYCLIC COMPOUND

The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Studies on Heterocyclic Enaminonitriles. IX. Ring Opening of 2-Amino-3-cyano-4,5-dihydrofurans by the Use of Benzoyl(and Acetyl) Chlorides

The reaction of 2-amino-3-cyano-4,5-dihydrofuran (Ia) with benzoyl(or acetyl) chloride in the presence of sodium hydride and sodium hydrogen carbonate gave 2-benzoyloxy(or acetoxy)ethylmalononitrile (IIa or IIIa).Similarly, 2-amino-3-cyano-5-methyl-4,5-di

Studies on Heterocyclic Enaminonitriles. VI. Synthesis of 2-Amino-3-cyano-4,5-dihydrofurans

Malononitrile reacts with 2-chloroethanol and 1-chloro-2-propanol (or 2-methyloxirane) in the presence of sodium ethoxide to give 2-amino-3-cyano-4,5-dihydrofuran (Ia) and 2-amino-3-cyano-5-methyl-4,5-dihydrofuran (Ib), respectively.The reaction of malono

Heterocyclic β-Enamino Esters, 38 - Comparative Investigations on Heterocyclic β-Enamino Nitriles. Synthesis of Heterocondensed Pyrimidines

β-Enamino nitriles of the furan- (1a - e), thiophene- (2), and pyrrole series (3) are obtained from malonodinitrile and oxiranes, thiirane, and N-tosylaziridine in the presence of bases; depending on the reaction conditions in the latter case (1:2)- (pyrr