27512-69-2Relevant academic research and scientific papers
Chiral synthons for 2-amino alcohols. Facile preparation of optically active amino hydroxy acids of biological interest
Ishibuchi, Seigo,Ishizuka, Tadao,Kunieda, Takehisa
, p. 1841 - 1852 (2016/02/17)
A promising method for the versatile synthesis of chiral 2-amino alcohols is provided by the enantioselective functionalization of the olefinic moiety of the simple heterocycle, 2-oxazolone, involving a stereodefined introduction of easily replaceable groups followed by stepwise substitution. Versatility of this method is shown in chiral synthesis of unusual hydroxy amino acids such as statine and hydroxyglutamic acid, which are the key components of bioactive peptides.
Synthesis of DL-Statine and DL-4-Amino-3-hydroxy-4-phenylbutanoic Acids via the Isoxazoline Route
Halling, Karen,Torssell, Kurt B. G.,Hazell, Rita G.
, p. 736 - 741 (2007/10/02)
1,3-Dipolar cycloaddition of chloronitrile oxide to N-allyltrichloroacetamides and subsequent reductive cleavage of the 3-methoxy-substituted isoxazolines gives methyl 3-hydroxy-4-trichloroacetamido esters which by acidic hydrolysis give the corresponding
