27547-04-2

Upstream product

• 13736-56-6 (2E)-1-(4-methylphenyl)-3-(4-nitrophenyl)prop-2-en-1-one 
• 102692-40-0 3-(4-nitrophenyl)-1-p-tolylprop-2-en-1-one 
• 555-16-8 4-nitrobenzaldehdye 
• 619-41-0 4-(bromoacetyl)toluene 

Downstream Products

• 91358-48-4 3-Chloro-2-hydroxy-3-(4-nitro-phenyl)-1-p-tolyl-propan-1-one 
• 91358-45-1 [(4S,5S)-2-Methylsulfanyl-4-(4-nitro-phenyl)-4,5-dihydro-oxazol-5-yl]-p-tolyl-methanone 
• 93850-87-4 [(4S,5R)-2,2-Dimethyl-5-(4-nitro-phenyl)-[1,3]dioxolan-4-yl]-p-tolyl-methanone 
• 91358-51-9 [2-Chloro-1-(4-nitro-phenyl)-3-oxo-3-p-tolyl-propyl]-thiocarbamic acid S-methyl ester 

Relevant academic research and scientific papers

N-Heterocyclic Carbene Catalyzed Oxidative Coupling of Alkenes/ α-Bromoacetophenones with Aldehydes: A Facile Entry to α,β-Epoxy Ketones

A novel, N-heterocyclic carbene (NHC) catalyzed direct oxidative coupling of styrenes with aldehydes has been described for the synthesis of α,β-epoxy ketones in good yields. This unprecedented regioselective oxidative coupling employs NBS/DBU/DMSO (DBU=1,8-diazabicyclo [5.4. 0] undec-7-ene, DMSO=dimethylsulfoxide, NBS=N-bromosuccinimide) as an oxidative system at ambient conditions. Additionally, first NHC-catalyzed Darzens reaction of α-bromoketones and aldehydes under mild reaction conditions has also been described. Interestingly, mechanistic studies have revealed the preferred reactivity of NHC with alkene/α-bromoketone rather than aldehydes, thus proceeding via the ketodeoxy Breslow intermediate.

Michael-type addition of hydroxide to alkynylselenonium salt: Practical use as a ketoselenonium ylide precursor

A novel synthetic method of ketodiphenylselenonium ylide from alkynylselenonium salt is described. A reaction of alkynylselenonium salt, hydroxide ion, and aldehyde in the presence of silver triflate and triethylamine gave oxiranylketones just as a trans-

Study of interactive free energy relationships on oxidation of phenyl styryl ketone and its substituted analogues by pyridinium chlorochromate in acid medium: A kinetic study

Kinetics of oxidation of phenyl styryl ketones (PSK) by pyridinium chlorochromate (PCC) has been investigated in acetic acid (90% v/v) medium in the presence of HClO4 in the temperature range 322 - 333K. The rate law of the reaction is as follows: -d[PCC]/dt=kK1K2[PSK] [PCC] [H+]/1+K2[PSK] The rates are enhanced by electron-releasing substituents in both the phenyl rings and decreased by electron-withdrawing substituents. The mechanism proposed envisages attack on >C = Cx and qy are found to be 0.236 and 0.252 at 323K.

SYNTHESIS OF cis-5-ARYL-4-AROYL-1,3-DIOXOLANES

The reaction of trans-3-aryl-2-aroyloxiranes containing electron-acceptor substituents in the aryl group with acetone under acid-catalysis conditions gives the corresponding cis-1,3-dioxolanes.