275800-97-0Relevant academic research and scientific papers
Selenium-catalyzed carbonylation of 2-aminothiazole with nitro aromatics to N-aryl-N′-2-thiazolylureas
Zhang, Xiaopeng,Tang, Zhaojing,Niu, Xueli,Li, Zhengwei,Fan, Xuesen,Zhang, Guisheng
, p. 5266 - 5270 (2016)
An efficient, economical, and phosgene-free procedure for the synthesis of N-aryl-N′-2-thiazolylureas is reported. With cheap and recyclable nonmetal selenium instead of noble metals as the catalyst, carbon monoxide instead of virulent phosgene as the carbonylation agent, the selenium-catalyzed carbonylation reaction of 2-aminothiazole can proceed smoothly in one-pot manner with a variety of nitro aromatics in the presence of triethylamine to afford the desired N-aryl-N′-2-thiazolylureas mostly in moderate to good yields. Selenium catalyst can be easily recovered due to its phase-transfer catalytic ability and reused without any significant degradation of its catalytic performance.
Heteroaryl-aryl ureas as IGF-1 receptor antagonists
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, (2008/06/13)
Methods for treating diseases associated with the activity of the insulin growth factor-1 receptor (IGF-1R), such as cancer, are provided. Methods for inhibiting cell growth and proliferation, especially of tumor cells, and promoting apoptosis are also pr
