275811-06-8

Basic information

• Product Name: Urea, N-(3-cyanophenyl)-N'-[4-hydroxy-2-[[4-(phenylmethyl)-1-piperidinyl]meth yl]phenyl]-
• CAS NO: 275811-06-8
• Molecular Formula: C27H28N4O2
• Molecular Weight: 440.545
• Mol File: 275811-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Urea, N-(3-cyanophenyl)-N'-[4-hydroxy-2-[[4-(phenylmethyl)-1-piperidinyl]meth yl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-(3-cyanophenyl)-N'-[4-hydroxy-2-[[4-(phenylmethyl)-1-piperidinyl]meth yl]phenyl]-(275811-06-8)
• EPA Substance Registry System: Urea, N-(3-cyanophenyl)-N'-[4-hydroxy-2-[[4-(phenylmethyl)-1-piperidinyl]meth yl]phenyl]-(275811-06-8)

Safety Data

• Hazardous Substances Data: 275811-06-8(Hazardous Substances Data)

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 16413-26-6 3-cyanophenyl isocyanate 

Relevant articles and documents

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists

Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils.