275823-77-3 Usage
Uses
Used in Chemical Synthesis:
BOC-DODA is used as a linker in chemical synthesis for the formation of complex molecules and bioconjugates. Its Boc-protected amino group allows for selective deprotection under mild acidic conditions, enabling the controlled assembly of multifunctional compounds.
Used in Pharmaceutical Industry:
BOC-DODA is used as a building block in the pharmaceutical industry for the synthesis of drug candidates and drug delivery systems. Its reactivity with various functional groups facilitates the development of novel therapeutic agents with improved pharmacokinetic and pharmacodynamic properties.
Used in Bioconjugation:
BOC-DODA is used as a coupling agent in bioconjugation for the attachment of biologically active molecules, such as peptides, proteins, and nucleic acids, to other molecules or surfaces. Its terminal amine provides a reactive handle for the formation of stable covalent bonds with target molecules, enhancing the specificity and functionality of the resulting bioconjugates.
Used in Materials Science:
BOC-DODA is used as a component in the development of advanced materials, such as polymers, dendrimers, and self-assembled structures. Its versatile reactivity and Boc-protected amino group enable the creation of materials with tailored properties and functions for various applications, including drug delivery, sensing, and catalysis.
Check Digit Verification of cas no
The CAS Registry Mumber 275823-77-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,5,8,2 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 275823-77:
(8*2)+(7*7)+(6*5)+(5*8)+(4*2)+(3*3)+(2*7)+(1*7)=173
173 % 10 = 3
So 275823-77-3 is a valid CAS Registry Number.
275823-77-3Relevant academic research and scientific papers
Steinebach, Christian,Sosi?, Izidor,Lindner, Stefanie,Bricelj, Ale?a,Kohl, Franziska,Ng, Yuen Lam Dora,Monschke, Marius,Wagner, Karl G.,Kr?nke, Jan,Gütschow, Michael
, p. 1037 - 1041 (2019)
A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.
